摘要
This study investigates the potential of polyphenols extracted from rose pepper in regulating diabetes mellitus and associated complications,including cardiovascular issues,lipid profile disturbances,enzyme activity denatur-ation,and liver function impairment in alloxan-induced diabetic mice.Following the induction of diabetes,a significant increase was observed in the levels of blood glucose,total cholesterol(TC),low-density lipoprotein(LDL),hepatic malondialdehyde(MDA),peroxide(H_(2)O_(2)),and superoxide anion O_(2)^(-)compared to the control group.Additionally,the reduction in high-density lipoprotein cholesterol(HDL)levels was associated with a decrease in the corresponding antioxidant enzymes,such as catalase(CAT),glutathione reductase(GR),gluta-thione peroxidase(GPx),and superoxide dismutase(SOD),in all diabetic mice.Moreover,the treatment with the rose pepper extract(150 and 250 mg/kg)for three weeks significantly decreased blood glucose,TC,LDL,MDA,O_(2)^(-),and H_(2)O_(2) levels in diabetic mice.Conversely,it increased serum HDL levels and reactivated hepatic anti-oxidant enzymes.The rich bioactive composition of the rose pepper extract,including gallic acid,amentoflavone,galloyl-shikimic acid,and methyl-3-O-caffeoylquinate,suggests a promising therapeutic effect.Toxicity testing in mice at a dosage of 2 g/kg showed no adverse effects,indicating the safety of consuming rose pepper poly-phenols.These findings support the potential of rose pepper polyphenols as a diabetic supplement,warranting further investigation into their synergistic effects with medications and potential incorporation into diabetic diets.
