摘要
In a recent study published in Nature,Huang,Wong and their colleagues identified G2E3 as the major histone H3 lysine 14 mono-ubiquitin(H3K14ub)ligase in mammalian cells.1 By coupling G2E3-dependent H3K14 ubiquitination to the recruitment of SUV39H at pericentromeric chromatin,the authors define a conserved pathway that guides the reassembly of H3K9me3 domains after mitosis and secures the proper compartmentalization of chromatin.
基金
Grants supporting this project are from the National Key Research and Development Program of China(2021YFA1300601)
National Natural Science Foundation of China grants(82273048 and 82341015).
