摘要
Objectives:The aim of this study was to explore the value of ultrasonography in screening the early stage of hepatic alveolar echinococcosis(HAE)in animal model,and to demonstrate characteristic imaging of early HAE in ultrasonography.Materials and methods:The early stage of experimentally induced secondary HAE in 157 rats was studied by ultrasonography.The features of all lesions were recorded,and compared with pathological results.Results:The sensitivity and specificity of ultrasonography was 93.5%,(95% confidence interval:76%-98%)and 83.3%(95%confidence interval:65%-93%),respectively.The typical features of early HAE in ultrasonography presented as solid hyperechoic masses and mixed lesions.Blood flow was detected in only three lesions by Color Doppler Flow Imaging.Calcifications were detected in 17 lesions which were larger than 8 mm.Lesions presented as single or multiple cystic structure,surrounded with the proliferation of small blood vessels,epithelioid cells,macrophages,fibroblasts,lymphocytes and fibrous tissue in the liver.Conclusions:Our data suggested that ultrasonography could be used as a screening method for early Echinococcus multilocularis lesions in the animal model.Calcification could be occurred in those lesions with fast growth of the parasite in short cycle.The typical features of early HAE presented as hyper-echoic with small size in ultrasonography.
基金
supported by the National Natural Science Foundation of China(81460267,81260232)
A project funded by Xinjiang Key Laboratory of Echinococcosis(XJDX0202-2013-4).
