摘要
N6-methyladenosine(m^(6)A)is a critical regulator of female reproductive physiology,yet existing reviews have focused predominantly on oocytes.The objective of this review is to systematically evaluate the regulatory effects ofm^(6)A throughout the pregnancy process.This review covers aspects such as oocyte maturation,granulosa cell dynamics,endometrial receptivity,immune homeostasis,and systemic adaptations,aiming to demonstrate the comprehensive regulatory capacity of m^(6)A in female reproduction.Dysregulated m^(6)A modifications in infertilityassociated pathologies,including endometriosis,polycystic ovary syndrome,and recurrent miscarriage,are analyzed to identify mechanistic links between an epitranscriptomic imbalance and reproductive dysfunction.The key findings indicate that m^(6)A is involved in the entire reproductive process and precisely coordinates stage-specific molecular programs within it,whereas aberrant methylation patterns disrupt gene networks essential for fertility.Notably,m^(6)A-modifying enzymes exhibit strong potential as diagnostic biomarkers for female reproductive disorders.The synthesis of the current evidence establishes m^(6)A dysregulation as a convergent pathogenic mechanism in diverse infertility etiologies,suggesting that the therapeutic modulation of m^(6)A pathways could address unmet clinical needs in reproductive medicine.
基金
supported by grants from the Medical Innovation Research Project of Science and Technology Innovation Action Plan of Shanghai Science and Technology Commission of China(No.20Z21900405)
Shanghai Famous Chinese Medicine Academic Experience Research Studio(China)(No.SHGZS-202240).
