摘要
Autophagy,a key cellular degradation pathway,is central to the pathogenesis of neurodegenerative diseases such as Alzheimer’s disease,Parkinson’s disease,and amyotrophic lateral sclerosis.Despite progress in understanding its role,critical questions remain.This perspective highlights pressing issues,including cell-type-specific autophagy regulation,interactions with other cellular pathways,and challenges in translating autophagy-modulating therapies to clinical practice.Addressing these questions will advance our understanding of neurodegenerative diseases and pave the way for novel therapeutics.
基金
supported by the National Natural Science Foundation of China(82471445 and 32170988)
the Talent Scientific Fund of Lanzhou University(561120215).
