摘要
Radical amidoalkynylations of olefins offer a powerful platform for the rapid construction of both C-N and C-O bonds,generating vicinal aminoalkynes which are frequently found in biologically active molecules.Herein,we developed a practical two-component radical amidoalkynylation of alkenes by using novel bifunctional alkynylsulfonamide reagents.The readily available alkynylsulfonamides served as both amidyl radical precursors and alkynyl radical acceptors.A variety of electron-rich alkenes,styrenes,and unactivated alkenes could be amidoalkynylated.Notably,the intramolecular amidoalkynylations of alkynylsulfonamides afforded highly functionalized pyrrolidines and tetrahydroisoquinolines.This transition metal-free method featured broad functional group compatibility.This method represents a significant advance in leveraging sulfonamide-based reagents for radical difunctionalizations of alkenes.
基金
the National Natural Science Foundation of China(grant no.22401027)
the Science and Technology Research Program of Chongqing Municipal Education Commission(grant no.KJQN202403115)
the Natural Science Foundation of Chongqing(grant no.CSTB2022NSCQ-MSX1006)
Venture&Innovation Support Program for Chongqing Overseas Returnees(grant no.cx2022035).
