摘要
目的考察亚胺培南西司他丁钠(IMI-CIL)与2种全营养混合液配伍的相容性,评估其通过Y型输液通路联合给药的可能性。方法模拟临床实际使用情况,将IMI-CIL和2种全营养混合液以3种体积比混合(1:1、2:1和4:1),室温[(25±2)℃]下放置4 h,并在0、0.5、1、2、4 h对配伍溶液外观性状、pH值、渗透压、不溶性微粒、脂肪乳粒径大小及分布、Zeta电位进行考察,同时采用高效液相色谱(HPLC)法测定各时间点亚胺培南和西司他丁含量。结果各组配伍溶液室温条件下放置4 h后,外观、pH值、渗透压、不溶性微粒、乳粒平均粒径(MDD)、多分散指数值(PDI)及Zeta电位均无显著变化,将IMI-CIL加入全营养混合液会导致pH值升高、渗透压和Zeta电位降低,但对脂肪乳MDD和PDI值无明显影响。西司他丁在4 h内相对百分含量均>93%,亚胺培南仅在配伍体积比为4:1时4 h内相对百分含量>90%,在配伍体积比为1:1和2:1时仅在1 h内相对百分含量>90%。结论IMI-CIL与2种全营养混合液可以在Y型输液通路中混合配伍使用,但在IMI-CIL与全营养混合液输注速度相近时,应保证两者在输液管中接触时间≤1 h。
Objective To investigate the compatibility of imipenem-cilastatin sodium with two total nutrient admixtures when mixed via a Y-site infusion channel and evaluate their co-administration feasibility.Methods Simulating clinical practice conditions.IMI-CIL was combined with two total nutrient admixtures at three volume ratios(1:1,2:1,and 4:1).The mixtures were stored at room temperature[(25±2)℃]for 4 hours.The appearance,pH,osmolality,insoluble particles,emulsion particle size,and zeta potential of the mixtures were investigated at time points of 0,0.5,1,2 and 4 hours.The contents of imipenem and cilastatin were also determined by HPLC.Results After 4 hours of storage,no significant changes were observed in the appearance,pH,osmolality,insoluble particles,MDD,PDI,and zeta potential of each group.The addition of IMI-CIL to total nutrient admixture caused an increase in pH and a decrease in osmolality and zeta potential,but there was no significant effect on the MDD and PDI of fat emulsion.The relative percentages of cilastatin were all higher than 93%within 4 hours.Imipenem was higher than 90%within 4 hours only in the 4:1 dosing volume ratio and within 1 hour only in the 1:1 and 2:1 dosing volume ratios.Conclusions IMI-CIL can be co-administered with two total nutrient admixtures via Y-site infusion channels.However,when the infusion rates of IMI-CIL and total nutrient admixtures are comparable,their contact time in the infusion channels should not exceed 1 hour.
作者
岳延涛
娄丽杰
赵婧铎
王丽果
李元培
赵亮
YUE Yantao;LOU Lijie;ZHAO Jingduo;WANG Liguo;LI Yuanpei;ZHAO Liang(Department of Pharmacy,Xuchang Central Hospital Affiliated to Henan University of Science and Technology,Xuchang Key Laboratory of Intelligent Pharmacy and Clinical Application of Drugs,Xuchang 461000,China)
出处
《医药导报》
2026年第3期500-507,共8页
Herald of Medicine
基金
河南省医学科技攻关计划项目(LHGJ20210949)。
关键词
全营养混合液
亚胺培南西司他丁钠
三腔袋
Y型输液通路
相容性
Total nutrient admixture
Imipenem-cilastatin sodium
Triple chambered bag
Y-site infusion channels
Compatibility
