摘要
慢性疼痛是一种常见的临床症状,严重影响患者的生活质量。传统的药物治疗往往效果有限且伴随诸多不良反应。大量的临床和基础研究致力于对慢性疼痛的发病机制及治疗手段的探索,这也使得慢性疼痛成为临床医学领域的热点研究方向。越来越多的研究表明,迷走神经通过多条通路参与疼痛信号转导过程,其机制可能涉及神经炎症、脑-肠轴及中枢调控系统等多方面。迷走神经刺激作为一种新兴的神经调控技术,因其独特的治疗机制和良好的临床应用前景而备受关注。系统阐述迷走神经参与痛觉调节的解剖学基础,以及迷走神经刺激镇痛的相关作用机制、临床应用现状、技术优化与未来发展方向,有望为临床更好地应用迷走神经刺激治疗慢性疼痛提供参考。
Chronic pain is a common clinical symptom that seriously affects patients’quality of life.Traditional pharmacological treatments often have limited efficacy and are accompanied by many adverse effects.A large number of clinical and basic studies have focused on exploring the pathogenesis and therapeutic approaches of chronic pain,making it a research hotspot in clinical medicine.Increasing evidence indicates that the vagus nerve participates in pain signal transmission through multiple pathways,and the underlying mechanisms may involve neuroinflammation,the brain-gut axis,and central regulatory systems.As an emerging neuromodulation technique,vagus nerve stimulation has attracted considerable attention because of its unique therapeutic mechanisms and promising clinical application prospects.A systematic overview of the anatomical basis of vagus nerve involvement in pain modulation,the analgesic mechanisms of vagus nerve stimulation,current clinical applications,technological optimization,and future development directions may provide references for better clinical application of vagus nerve stimulation in the treatment of chronic pain.
作者
刘晴晴
陈斌
徐聪
林万庆
LIU Qingqing;CHEN Bin;XU Cong;LIN Wanqing(First Clinical Medical College,Fujian University of Traditional Chinese Medicine,Fuzhou 350004;Department of Rehabilitation Medicine,People’s Hospital Affiliated to Fujian University of Traditional Chinese Medicine,Fuzhou 350004;Department of Acupuncture and Moxibustion,Rehabilitation Hospital Affiliated to Fujian University of Traditional Chinese Medicine,Fuzhou 350004,China)
出处
《中南大学学报(医学版)》
2025年第12期2438-2448,共11页
Journal of Central South University (Medical Science)
基金
国家自然科学基金(JCZX202307)
福建省自然科学基金(2023J01846)。
