GABPα_(2)β_(2) tetramer deficiency impairs natural killer cell maturation,compromising cytotoxicity and resistance against melanoma
GABPα_(2)β_(2) 四聚体缺失影响自然杀伤细胞分化和功能从而削弱其拮抗黑色素瘤能力
摘要
Natural killer(NK)cells are cytotoxic innate lymphocytes crucial for rapid immune responses against pathogens and tumors[1].A dynamic network of transcription factors(TFs)orchestrates NK cell specification,development,and maturation in a sequential,coordinated manner[2].
基金
supported in part by grants Biological BreedingMajor Projects(2023ZD04050 and 2023ZD04070)
the National Natural Scientific Foundation of China(32130039 and 31970831)
the National Key Research and Development Program of China(2024YFA1802400 and 2023YFF1000901)
“Hundred”Level Of High-Level Innovative Talents in Guizhou Province(GCC[2023]040)
the Pinduoduo-China Agricultural University Research Fund(PC2023B01011)
the Innovation Program of Chinese Academy of Agricultural Sciences(CAAS-CSAB-202401).
