Role and mechanism of miR-183 targeting PTEN to regulate the AKT signaling pathway in the progression of diabetic nephropathy
摘要
Objective To investigate the mechanism by which microRNA-183(miR-183)regulates the progression of diabetic nephropathy(DN)through targeting phosphatase and tensin homolog deleted on chromosome 10(PTEN)and modulating the AKT signaling pathway,and to identify potential therapeutic targets for DN.Methods(1)Bioinformatic analysis of miRNA expression:MiRNA expression datasets from diabetic nephropathy(DN)and control samples were obtained from the Gene Expression Omnibus database.
