摘要
微波消融(microwave ablation,MWA)是一种微创的热消融治疗手段,目前已广泛应用于肺癌的局部治疗。MWA不仅能够局部有效地诱导肿瘤细胞坏死,还能通过调控肿瘤免疫微环境(tumor immune microenvironment,TIME)诱发潜在远端效应来激活抗肿瘤免疫效应;此外,MWA联合抗肿瘤免疫药物可能发挥协同效应,这为肺癌患者的治疗提供了新的方向。本文综述了MWA治疗肺癌过程中抗肿瘤免疫反应激活的机制,旨在为肺癌未来的治疗策略提供理论基础和实践指导。
Microwave ablation(MWA)is a minimally invasive thermal ablation treatment method and has been widely applied in the local treatment of lung cancer.MWA not only can effectively induce local tumor cell necrosis,but also can activate anti-tumor immune responses by regulating the tumor immune microenvironment(TIME)and inducing potential distant effects.In addition,the combination of MWA and anti-tumor immune drugs may exert a synergistic effect,which provides a new direction for the treatment of lung cancer patients.This article reviews the mechanisms of activation of anti-tumor immune responses during MWA treatment of lung cancer,aiming to provide a theoretical basis and practical guidance for future treatment strategies of lung cancer.
作者
杨振宇
陈晓雯
蒋军红
Zhenyu YANG;Xiaowen CHEN;Junhong JIANG(Department of Respiratory and Critical Care Medicine,The Fourth Affiliated Hospital of Soochow University(Suzhou Dushu Lake Hospital),Suzhou 215000,China)
出处
《中国肺癌杂志》
2025年第11期875-881,共7页
Chinese Journal of Lung Cancer
关键词
微波消融
肺肿瘤
免疫激活
肿瘤免疫微环境
免疫治疗
Microwave ablation
Lung neoplasms
Immune activation
Tumor immune microenvironment
Immunotherapy
