摘要
目的探讨胃息肉患者不同中医证型与RNF180/Septin9基因甲基化的相关性。方法回顾性横断面研究。收集2022年3月-2024年7月中国中医科学院望京医院住院治疗并参与RNF180/Septin9基因甲基化检测的143例胃息肉患者病历资料,对患者性别、年龄、烟酒史、家族史、病理类型、RNF180/Septin9基因甲基化检测结果等临床资料进行回顾性分析,按中医证型诊断标准分为湿热内蕴、肝胃不和、脾胃虚寒、胃络瘀血、痰湿中阻5种证型,分析胃息肉患者中医证型、病理类型与RNF180/Septin9基因甲基化的相关性。结果143例胃息肉患者以湿热内蕴证居多;脾胃虚寒证RNF180/Septin9基因甲基化阳性率高于肝胃不和证(P<0.01)及胃络瘀血证(P<0.05);在胃息肉中医证型中,脾胃虚寒证与RNF180/Septin9基因甲基化呈正相关(r=0.233,P<0.05);在病理类型中,炎性息肉与RNF180/Septin9基因甲基化呈正相关(r=0.246,P<0.05)。结论中医证型为脾胃虚寒、病理类型为炎性息肉的胃息肉患者更易发生RNF180/Septin9基因甲基化,可提示潜在风险。
Objective To explore the correlation between different TCM syndrome types and the methylation of RNF180/Septin9 genes of patients with gastric polyps.Methods A retrospective cross-sectional study.The data of patients with gastric polyps diagnosed by the HIS system at the Wangjing Hospital,China Academy of Chinese Medical Sciences from March 2022 to July 2024 were collected,and the information of patients'gender,age,smoking and drinking history,family history,pathological type,and RNF180/Septin9 gene methylation detection results were under a retrospective study.According to the inclusion and exclusion criteria,143 patients with gastric polyps were selected,and they were classified into five TCM syndrome types according to the diagnostic standard of TCM syndromes:damp heat accumulation,liver-stomach disharmony,spleen-stomach coldness,stomach blood stasis,and phlegm dampness obstruction.The correlation between the TCM syndrome types,pathological types,and RNF180/Septin9 gene methylation of gastric polyps was analyzed.Results Most of 143 patients with gastric polyp had dampness-heat syndrome.The positive rate of RNF180/Septin9 gene methylation in spleen-stomach deficiency cold syndrome was higher than that in liver-stomach disharmony syndrome(P<0.01),and stomach stasis syndrome(P<0.05);in TCM syndrome type of gastric polyp,spleen-stomach deficiency cold syndrome was positively correlated with RNF180/Septin9 gene methylation(r=0.233,P<0.05);in pathological type,inflammatory polyp was positively correlated with RNF180/Septin9 gene methylation(r=0.246,P<0.05).Conclusion Patients with gastric polyp whose TCM syndrome type is spleen-stomach deficiency cold and pathological type as inflammatory polyp are more likely to have RNF180/Septin9 gene methylation,which can alert potential risks.
作者
白欣
郭东琪
许爱丽
王源
白建琦
张平
Bai Xin;Guo Dongqi;Xu Aili;Wang Yuan;Bai Jianqi;Zhang Ping(Department of Pathology,Wangjing Hospital,China Academy of Chinese Medical Sciences,Beijing 100102,China;Department of Gastroenterology,Wangjing Hospital,China Academy of Chinese Medical Sciences,Beijing 100102,China)
出处
《国际中医中药杂志》
2026年第1期22-27,共6页
International Journal of Traditional Chinese Medicine
基金
中国中医科学院望京医院高水平中医医院建设项目中医药临床循证研究专项(WJYY-XZKT-2023-07)
中国中医科学院基本科研优秀青年科技人才培养专项(ZZ15-YQ-028)。
