摘要
Ticks can transmit many pathogens,including arboviruses,to their vertebrate hosts.Arboviruses must overcome or evade defense mechanisms during their passage from the tick gut to the hemolymph,salivary glands,and the feeding site in the host skin.This review summarizes current knowledge of defense mechanisms in specific tick tissues and at the feeding site in the host skin.We discuss the possible roles of these defense mechanisms in viral infection and transmission.The responses of tick salivary proteins to arbovirus infection are also discussed.This review provides information that may help accelerate research on virus–tick interactions.
基金
supported by the National Natural Science Foundation of China(grant numbers 32160124 and 82102433)
the Hainan Provincial Natural Science Foundation of China(grant numbers 822RC711 and 821QN254).
