摘要
目的分析男性不育患者血清抗精子抗体、抑制素B与精液参数及性激素水平的关系。方法选取2022年9月至2024年3月民航总医院收治的86例男性不育患者作为研究对象,根据精液质量检测结果,将45例患者纳入少精子组,41例患者纳入弱精子组。另选取同期86例进行孕前精液质量检测的健康男性设为对照组。比较三组血清抗精子抗体阳性率、抑制素B水平。采用Spearman法和Pearson法分析抗精子抗体、抑制素B与精液参数及性激素水平的相关性。结果少精子组和弱精子组血清抗精子抗体阳性率显著高于对照组,抑制素B水平显著低于对照组(P<0.05)。少精子组精子浓度及精液体积依次低于弱精子组和对照组,弱精子组精子活力和前向运动精子百分率(PR)依次低于少精子组和对照组(P<0.05)。与对照组比较,少精子组和弱精子组卵泡刺激素(FSH)、催乳素(PRL)、黄体生成素(LH)、雌二醇(E_(2))水平均升高,睾酮(T)水平均降低(P<0.05);与弱精子组比较,少精子组FSH、LH水平升高,PRL、T、E_(2)水平降低(P<0.05)。血清抗精子抗体与T、精子浓度、精液体积、精子活力及PR水平呈显著负相关,与FSH、PRL、LH、E_(2)呈显著正相关(P<0.05);抑制素B与T、精子浓度、精液体积、精子活力及PR水平呈显著正相关,与FSH、PRL、LH、E_(2)呈显著负相关(P<0.05)。结论男性不育患者血清抗精子抗体阳性率升高,抑制素B水平下降,二者与精液参数及性激素水平密切相关。
Objective To analyze the relationship between serum anti-sperm antibodies,inhibin B with semen parameters and sex hormone levels in male infertile patients.Methods A total of 86 male infertile patients admitted to the Civil Aviation General Hospital from September 2022 to March 2024 were selected as study subjects.Based on semen quality test results,45 patients were assigned to the oligospermia group and 41 patients were assigned to the asthenospermia group.Additionally,86 healthy males undergoing pre-pregnancy semen quality testing during the same period were selected as control group.The serum anti-sperm antibody positivity rate and inhibin B levels were compared among the three groups.Spearman and Pearson correlation analyses were performed to examine the relationships between anti-sperm antibodies,inhibin B with semen parameters and sex hormone levels.Results The serum anti-sperm antibody positivity rate was significantly higher in the oligospermia and asthenospermia groups compared to the control group,while inhibin B levels were significantly lower than the control group(P<0.05).Sperm concentration and semen volume in the oligospermia group were lower than those in the asthenospermia group and the control group,respectively(P<0.05).Sperm motility and progressive motility rate(PR)in the asthenospermia group were lower than those in the oligospermia group and the control group,respectively(P<0.05).Compared with the control group,both the oligospermia and asthenospermia groups exhibited elevated levels of follicle-stimulating hormone(FSH),prolactin(PRL),luteinizing hormone(LH)and estradiol(E_(2)),while testosterone(T)levels were reduced(P<0.05).Compared with the asthenospermia group,the oligospermia group exhibited elevated FSH and LH levels,while PRL,T and E_(2) levels were reduced(P<0.05).Serum anti-sperm antibodies showed significantly negative correlations with T,sperm concentration,semen volume,sperm motility,and PR levels,and significantly positive correlations with FSH,PRL,LH and E_(2)(P<0.05).Inhibin B showed significantly positive correlations with T,sperm concentration,semen volume,sperm motility and PR levels,and significantly negative correlations with FSH,PRL,LH and E_(2)(P<0.05).Conclusions Serum anti-sperm antibody positivity rates are elevated in male infertile patients,while inhibin B levels are decreased.Both findings are closely associated with semen parameters and sex hormone levels.
作者
李锦楠
崔亮
韩旭
李景敏
LI Jinnan;CUI Liang;HAN Xu;LI Jingmin(Department of Urology,Civil Aviation General Hospital,Beijing 100123,China)
出处
《中国性科学》
2025年第12期9-14,共6页
Chinese Journal of Human Sexuality
基金
吴阶平医学基金会临床科研专项资助基金项目(320.6750.2022-15-7)。
关键词
男性不育
抗精子抗体
抑制素B
精液参数
性激素
Male infertility
Anti-sperm antibodies
Inhibin B
Semen parameters
Sex hormone
