摘要
目的:分析参蓉补脑汤联合常规治疗在缺血性脑卒中后血管性痴呆患者中的应用效果。方法:选取2022年12月—2024年9月北京王府中西医结合医院脑病科收治的82例缺血性脑卒中后血管性痴呆患者,采用抽签法随机分为两组,各41例。对照组开展常规治疗,观察组在对照组基础上联用参蓉补脑汤。对比两组炎性因子、氧化应激指标、认知功能及整体疗效。结果:治疗后,观察组肿瘤坏死因子-α、超敏C反应蛋白、丙二醛水平低于对照组(P<0.001),超氧化物歧化酶水平高于对照组(P<0.001)。治疗后,观察组简明精神状态量表、蒙特利尔认知评估量表评分较对照组高(P<0.05)。观察组治疗总有效率高于对照组(P=0.026)。结论:参蓉补脑汤在缺血性脑卒中后血管性痴呆患者中的应用效果显著,可减轻炎症及氧化应激反应,改善认知功能。
Objective:To analyze the application effect of Shenrong Bunao decoction combined with conventional therapy in patients with vascular dementia after ischemic stroke.Methods:From December 2022 to September 2024,a total of 82 patients with vascular dementia after ischemic stroke admitted to the Department of Encephalopathy at Beijing Royal Integrative Medicine Hospital were selected and randomly divided into two groups by lottery method,with 41 cases in each group.The control group was given conventional therapy,and the observation group was treated with Shenrong Bunao decoction on the basis of the control group.The inflammatory factors,oxidative stress indexes,cognitive function and overall efficacy were compared between the two groups.Results:After treatment,the levels of tumor necrosis factor-α,high-sensitivity C-reactive protein,and malondialdehyde in the observation group were lower than those in the control group(P<0.001),and the levels of superoxide dismutase in the observation group was higher than that in the control group(P<0.001).After treatment,the scores of mini-mental state examination and Montreal cognitive assessment in the observation group were higher than those in the control group(P<0.05).The overall response rate of treatment in the observation group was higher than that in the control group(P=0.026).Conclusion:Shenrong Bunao decoction has a significant effect in patients with vascular dementia after ischemic stroke,and can alleviate inflammation and oxidative stress response,and improve cognitive function.
作者
周雷
Zhou Lei(Department of Encephalopathy,Beijing Royal Integrative Medicine Hospital,Beijing 102200,China)
出处
《中外医药研究》
2025年第31期102-104,共3页
JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH
关键词
参蓉补脑汤
血管性痴呆
缺血性脑卒中
炎性因子
氧化应激
认知功能
Shenrong Bunao decoction
Vascular dementia
Ischemic stroke
Inflammatory factor
Oxidative stress
Cognitive function
