摘要
目的:评估环泊酚复合瑞芬太尼在肥胖患者无痛胃镜麻醉中的应用效果。方法:选取2022年1月—2024年7月于首都医科大学附属北京安贞医院南充医院(南充市中心医院)行无痛胃镜检查的肥胖患者98例,采用随机数字表法分为对照组和观察组,各49例。对照组实施丙泊酚复合瑞芬太尼麻醉,观察组实施环泊酚复合瑞芬太尼麻醉。比较两组麻醉相关指标、生命体征、麻醉不良反应发生率。结果:两组麻醉起效时间比较,无统计学差异(P>0.05);观察组苏醒时间、离室时间较对照组短,差异有统计学意义(P<0.05)。麻醉前,两组平均动脉压(MAP)、心率(HR)、经皮血氧饱和度(SpO_(2))水平比较,无统计学差异(P>0.05)。胃镜检查开始时、镜体过声门时,观察组MAP、SpO_(2)水平高于对照组,差异有统计学意义(P<0.001);HR水平低于对照组,差异有统计学意义(P<0.001)。检查结束时,观察组MAP、SpO_(2)水平高于对照组,差异有统计学意义(P<0.05)。检查结束时,两组HR水平比较,无统计学差异(P>0.05)。与对照组相比,观察组麻醉不良反应发生率更低,差异有统计学意义(P<0.001)。结论:环泊酚复合瑞芬太尼应用在肥胖患者无痛胃镜检查中的麻醉效果较好,能够缩短其苏醒时间与离室时间,稳定生命体征,降低麻醉不良反应发生风险。
Objective:To evaluate the application effect of cipepofol combined with remifentanil in painless gastroscopy anesthesia of obese patients.Methods:A total of 98 obese patients who underwent painless gastroscopy at Nanchong Hospital of Beijing Anzhen Hospital Affiliated to Capital Medical University(Nanchong Central Hospital)from January 2022 to July 2024 were selected and divided into control group and observation group according to random number table method,with 49 cases in each group.The control group was anesthetized with propofol combined with remifentanil,while the observation group was anesthetized with cipepofol combined with remifentanil.The anesthesia-related indicators,vital signs,and the incidence of adverse reactions were compared between the two groups.Results:There was no significant difference in the onset time of anesthesia between the two groups(P>0.05).Compared with the control group,the recovery time and time from room in the observation group were shorter,the difference was statistically significant(P<0.05).Before anesthesia,there were no statistically significant differences in mean arterial pressure(MAP),heart rate(HR),and transcutaneous oxygen saturation(SpO_(2))between the two groups(P>0.05).At the beginning of gastroscopy and when the scope crossed the glottis,compared with the control group,the MAP and SpO_(2) levels of the observation group were higher,the difference was statistically significant(P<0.001),and the HR level was lower,the difference was statistically significant(P<0.001).At the end of the examination,compared with the control group,the MAP and SpO_(2) levels of the observation group were higher,the difference was statistically significant(P<0.05).At the end of the examination,the difference in HR level between the two groups was not statistically significant(P>0.05).Compared with the control group,the incidence of adverse reactions of anesthesia in the observation group was lower,the difference was statistically significant(P<0.001).Conclusion:The application of cipepofol combined with remifentanil shows good anesthetic effect in obese patients undergoing painless gastroscopy,and can shorten the recovery time and discharge time,stabilize vital signs,and reduce the risk of adverse reactions of anesthesia.
作者
吴俊东
Wu Jundong(Department of Anesthesia,Nanchong Hospital of Beijing Anzhen Hospital Affiliated to Capital Medical University(Nanchong Central Hospital),Nanchong 637000,Sichuan Province,China)
出处
《中外医药研究》
2025年第31期59-62,共4页
JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH
关键词
环泊酚
瑞芬太尼
肥胖
无痛胃镜
麻醉效果
Cipepofol
Remifentanil
Obesity
Painless gastroscopy
Anesthetic effect
