摘要
目的系统评估不同获卵数分层对行体外受精-胚胎移植(IVF-ET)治疗的不孕症患者临床结局的影响,为技术选择的个体化方案提供科学依据。方法回顾性收集2023年1月至2025年6月就诊于漯河市中心医院生殖医学与遗传中心的接受辅助生殖技术(ART)治疗的不孕症患者292例为研究对象,依据获卵数将其划分为三组:A组(低获卵数组,≤5枚,42例)、B组(理想获卵数组,6~15枚,192例)、C组(高获卵数组,≥16枚,58例)。比较三组患者胚胎实验室指标、临床结局指标及妊娠期间并发症的发生情况。结果三组患者除基础促卵泡生成素(FSH)差异有统计学意义(P<0.05)之外,其余一般资料无统计学差异(P>0.05)。C组的获卵数、平均可用胚胎数显著高于A组和B组,差异有统计学意义(P<0.05);同时,B组的平均优质胚胎率、囊胚形成率、优质囊胚形成率显著高于A组和C组,差异有统计学意义(P<0.05);三组的受精率比较,差异无统计学意义(P>0.05)。B组的临床妊娠率显著高于A组和C组,差异有统计学意义(P<0.05);三组的流产率比较,差异无统计学意义(P>0.05)。三组患者取卵周期中,C组中重度卵巢过度刺激综合征(OHSS)发生率显著高于A组和B组,差异有统计学意义(P<0.05)。结论当获卵数为6~15枚时,不孕患者行IVF-ET能够获得较高的临床妊娠率,较好的囊胚质量指标及较低的中重度OHSS发生率。
Objective To systematically evaluate the impact of different oocyte yield strata on the clinical outcomes of infertile patients undergoing in vitro fertilization–embryo transfer(IVF-ET),and to provide a scientific basis for individualized selection of treatment strategies.Methods A total of 292 infertile patients who received assisted reproductive technology(ART)at the Reproductive Medicine and Genetics Center of Luohe Central Hospital from January 2023 to June 2025 were retrospectively enrolled.According to the number of oocytes retrieved,patients were divided into three groups:group A(low oocyte yield,≤5 oocytes,n=42),group B(optimal oocyte yield,6–15 oocytes,n=192),and group C(high oocyte yield,≥16 oocytes,n=58).Embryology laboratory parameters,clinical outcome indicators,and pregnancy complications were compared among the three groups.Results Except for basal follicle-stimulating hormone(FSH),which showed a statistically significant difference among the three groups(P<0.05),there were no significant differences in other baseline characteristics(P>0.05).The number of oocytes retrieved and the mean number of usable embryos in group C were significantly higher than those in groups A and B(P<0.05).However,the mean good-quality embryo rate,blastocyst formation rate,and good-quality blastocyst formation rate in group B were significantly higher than those in groups A and C(P<0.05).There was no statistically significant difference in fertilization rate among the three groups(P>0.05).The clinical pregnancy rate in group B was significantly higher than that in groups A and C(P<0.05),while the miscarriage rate did not differ significantly among the three groups(P>0.05).Among the three groups of patients during the oocyte retrieval cycle,the incidence of moderate to severe ovarian hyperstimulation syndrome(OHSS)in Group C was significantly higher than that in Group A and Group B,with a statistically significant difference(P<0.05).Conclusion When the number of retrieved oocytes is 6–15,infertile patients undergoing IVF-ET can achieve a higher clinical pregnancy rate,better blastocyst quality indicators,and a lower incidence of moderate-to-severe OHSS.
作者
胥博
谢文燕
张怡
陈媛
邵帅
付秀虹
李荣香
XU Bo;XIE Wenyan;ZHANG Yi;SHAO Shuai;FU Xiuhong;LI Rongxiang(Reproductive Medicine and Genetics Center,Luohe Central Hospital,Luohe,Henan 462000,China)
出处
《临床研究》
2025年第12期13-17,共5页
Clinical Research
基金
2022年河南省医学科技攻关联合共建项目(LHGJ20221028)。
关键词
体外受精-胚胎移植
获卵数
不孕症
临床结局
in vitro fertilization–embryo transfer
number of oocytes retrieved
infertility
clinical outcome
