摘要
The serine hydrolase(SH)superfamily,one of the largest enzyme groups in mammals with over 200 members,is characterized by a serine-containing catalytic triad within its active site1.These enzymes hydrolyze amide and/or ester bonds through a nucleophilic attack mediated by the catalytic serine residue.SHs are expressed across various mammalian tissues and play critical roles in diverse physiological and pathological processes.
