摘要
目的:观察补肾解毒汤联合艾灸治疗慢性肾衰竭(CRF)氮质血症期患者的效果。方法:选取2021-2023年该院收治80例CRF氮质血症期患者进行前瞻性研究,按随机数字表法将其分为研究组(n=40)和对照组(n=40)。对照组给予艾灸治疗,研究组在对照组基础上联合补肾解毒汤治疗。比较两组临床疗效,治疗前后中医证候积分、肾功能指标[血肌酐(Scr)、内生肌酐清除率(Ccr)、血尿素氮(BUN)、肾小球滤过率(GFR)]水平、炎性因子[肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)]水平,以及不良反应发生率。结果:研究组治疗总有效率为92.50%,高于对照组的72.50%,差异有统计学意义(P<0.05);治疗后,两组面色晦暗、纳呆食少、乏力倦怠、脘腹胀满等中医证候积分均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);治疗后,两组Scr、BUN水平均低于治疗前,且研究组低于对照组,两组Ccr、GFR水平均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);治疗后,两组TNF-α、IL-6、hs-CRP水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:补肾解毒汤联合艾灸治疗CRF氮质血症期患者可提高治疗总有效率,改善肾功能指标水平,以及降低中医证候积分和炎性因子水平的效果优于单纯艾灸治疗。
Objective:To observe effects of Bushen Jiedu decoction combined with Moxa-wool moxibustion in treatment of chronic renal failure(CRF)patients at azotemia stage.Methods:A prospective study was conducted on 80 patients with CRF at azotemia stage in this hospital from 2021 to 2023.They were divided into study group(n=40)and control group(n=40)by using the random number table method.The control group was treated with Moxa-wool moxibustion,while the study group was treated with Bushen Jiedu decoction on the basis of that of the control group.The clinical efficacy,the traditional Chinese medicine(TCM)syndrome score,the levels of renal function indexes[serum creatinine(Scr),endogenous creatinine clearance rate(Ccr),blood urea nitrogen(BUN),glomerular filtration rate(GFR)]and inflammatory factors[tumor necrosis factor-α(TNF-α),hyper-sensitive C-reactive protein(hs-CRP),interleukin-6(IL-6)]before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the study group was 92.50%,which was higher than 72.50%in the control group,and the difference was statistically significant(P<0.05).After the treatment,the scores of TCM syndromes such as dull complexion,poor appetite,fatigue,abdominal distension and fullness in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of Scr and BUN in the two groups were lower than those before the treatment,and those in the study group were lower than those in the control group;the levels of Ccr and GFR in the two groups were higher than those before the treatment,and those in the study group were higher than those in the control group;and the differences were statistically significant(P<0.05).After the treatment,the levels of TNF-α,IL-6 and hs-CRP in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Bushen Jiedu decoction combined with Moxa-wool moxibustion in the treatment of the CRF patients at azotemia stage can improve the total effective rate of treatment,improve the levels of renal function indexes,and reduce the TCM syndrome scores and the levels of inflammatory factors.Moreover,it is superior to simple Moxa-wool moxibustion treatment.
作者
吴新萍
WU Xinping(Department of Nephrology of Zhumadian Hospital of Traditional Chinese Medicine,Zhumadian 463000 Henan,China)
出处
《中国民康医学》
2025年第20期122-124,135,共4页
Medical Journal of Chinese People’s Health
关键词
补肾解毒汤
艾灸
慢性肾衰竭
氮质血症期
肾功能
炎性因子
中医证候积分
Bushen Jiedu decoction
Moxa-wool moxibustion
Chronic renal failure
Azotemia stage
Renal function
Inflammatory factor
TCM syndrome score
