摘要
减重手术目前是治疗肥胖及其相关代谢疾病最有效的方式,近年来受到越来越多的关注。肠道菌群失调是代谢性炎症过程的重要激发因素,减重手术在减轻体重的同时也改变了肠道菌群,肠道菌群的变化在一定程度上改善患者的血糖、血压、血脂和胰岛素抵抗水平,有助于减轻机体炎症状态和维持减重效果。本文就减重手术对肠道菌群、肥胖、动脉粥样硬化(AS)、2型糖尿病(T2DM)和非酒精性脂肪肝(NAFLD)的影响及相关机制的研究进展作一综述。
Bariatric surgery is currently the most effective way to treat obesity and its related metabolic diseases,and has attracted more and more attention in recent years.Dysbiosis of intestinal flora is an important trigger for metabolic inflammatory process.Bariatric surgery changes the gut microbiota as well as the weight loss,the changes of gut microbiota can improve the blood glucose,blood pressure,blood lipids and insulin resistance of patients to some extent,and help to reduce the inflammatory state and maintain the weight loss of the body.In this review,the effects of bariatric surgery on the intestinal flora,obesity,atherosclerosis(AS),T2DM and NAFLD and the related mechanisms were reviewed.
作者
邓垚
谢壁成
吴边
兰丹凤
Deng Yao;Xie Bicheng;Wu Bian;Lan Danfeng(Department of Gastroenterology,The First People's Hospital of Yunnan Province,650032 Kunming,China;Yunnan Digestive Disease Clinical Medical Center,650032 Kunming,China;Department of Gastrointestinal and Bariatric Metabolic Surgery,The First People's Hospital of Yunnan Province,650032 Kunming,China;Yunnan Key Laboratory of Innovative Application of Traditional Chinese Medicine,650032 Kunming,China)
出处
《中华肥胖与代谢病电子杂志》
2025年第1期70-75,共6页
Chinese Journal Of Obesity and Metabolic Diseases:Electronic Edition
基金
云南省“兴滇英才计划”青年拔尖人才专项(YNWRQNBJ-2020-236)
昆明理工大学-云南省第一人民医院医学联合专项基金(KUST-KH2022013Y)
云南省科技厅-昆明医科大学应用基础研究联合专项(202301AY070001-058、202401AY070001-040)
关键词
减重手术
肠道菌群
动脉粥样硬化
2型糖尿病
非酒精性脂肪肝
Bariatric surgery
Intestinal flora
Atherosclerosis
Type 2 diabetes mellitus
Nonalcoholic fatty liver disease
