摘要
目的:探讨体质指数(body mass index,BMI)、身体圆度指数(body round index,BRI)、内脏肥胖指数(visceral adiposity index,VAI)、脂质堆积产物指数(lipid accumulation product,LAP)以及身体形态指数(a body shape index,ABSI)5个肥胖指标与中老年人群认知功能之间的关联性。方法:基于2019—2022年湖北省武汉市与十堰市的横断面调查数据,排除自我报告患有痴呆或帕金森病以及基本信息缺失者后,最终纳入6917例研究对象。运用多元线性回归和Logistic回归模型分别分析上述指标与认知功能之间的关联,进一步应用限制性立方样条(restricted cubic spline,RCS)模型探究上述指标与轻度认知功能障碍(mild cognitive impairment,MCI)风险的剂量-反应关系。结果:本研究纳入的6917例参与者中包括男性3338例(48.3%),女性3579例(51.7%),共670例(占比9.7%)参与者被划分为MCI。随着BRI和ABSI增加,MMSE得分呈降低趋势,而MCI风险呈升高趋势(P趋势均<0.001),且BRI和ABSI与MCI风险之间呈线性剂量-反应关系。BRI、ABSI和LAP Q4组MCI发生风险显著高于参照组(Q1组)[OR(95%CI)分别为1.58(1.23,2.03)、2.54(1.68,3.86)和1.38(1.08,1.76),P值均<0.05]。未发现BMI和VAI与认知功能之间的显著关联。结论:高BRI、ABSI和LAP可能是认知功能下降的危险因素,且BRI和ABSI与MCI风险之间可能存在一定剂量-反应关系。
Objective:To investigate the associations of five obesity indicators,body mass index(BMI),body round index(BRI),visceral adiposity index(VAI),lipid accumulation product(LAP),and a body shape index(ABSI),with the risk of mild cognitive impairment(MCI)in middle-aged and older adults.Methods:This cross-sectional study recruited participants from Wuhan and Shiyan cities in Hubei province during 2019 and 2022.After excluding individuals with self-reported dementia or Parkinson's disease and missing general characteristics,a total of 6,917 participants were included in this study.Multiple linear regression and logistic regression models were used to evaluate the associations of body mass index and novel obesity indicators with the cognitive function.Restricted cubic spline model was used to explore the nonlinear relationships between obesity indicators and MCI.Results:Among the 6917 participants in this study,3338(48.3%)were males and 3579(51.7%)were females.A total of 670(9.7%)participants were identified as MCI.Increased BRI and ABSI were associated with decreased MMSE score and raised MCI risk(P trend<0.001).After adjusting for confounding,compared to the Q1 subgroup,individuals in the BRI,ABSI and LAP Q4 subgroup respectively showed increased MCI risk[OR(95%CI)=1.58(1.23,2.03),2.54(1.68,3.86),1.38(1.08,1.76)].RCS confirmed the linear dose-response relationships of BRI and ABSI with MCI risk(both P for non-linear associations were>0.05).However,BMI and VAI were not found to be correlated with MCI risk.Conclusion:High BRI,ABSI and LAP may be risk factors for cognitive decline,and BRI and ABSI may present a potential dose-response relationship with MCI risk.
作者
黄慧
高志慧
刘博思
洪诗茹
管鑫
郭欢
Hui HUANG;Zhihui GAO;Bosi LIU;Shiru HONG;Xin GUAN;Huan GUO(Department of Occupational and Environmental Health,State Key Laboratory of Environment&Health(Incubating),Ministry of Education,School of Public Health,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China)
出处
《阿尔茨海默病及相关病杂志》
2025年第4期239-247,252,共10页
Chinese Journal of Alzheimer's Disease and Related Disorders
基金
国家自然科学基金(82373667)。
关键词
体质指数
新型肥胖指标
认知功能
横断面研究
Bbody mass index
Novel obesity indicators
Cognitive function
Cross-sectional study
