摘要
目的:探讨细菌溶解产物胶囊联合孟鲁司特治疗小儿支气管哮喘的疗效及其对肺功能的影响。方法:选取2021年1月—2024年1月重庆市渝北区人民医院收治的120例支气管哮喘患儿作为研究对象,按照信封随机分组法对纳入患儿进行分组,包括对照组(n=59,采用孟鲁司特治疗)、联合组(n=61,采用细菌溶解产物胶囊联合孟鲁司特治疗),共两组。比较两组临床治疗效果以及安全性评价。结果:联合组治疗显效、有效和无效占比分别为(22.95%)、(67.21%)和(9.84%),对照组为(13.56%)、(62.71%)、(23.73%);联合组总有效率高于对照组,差异有统计学意义(P<0.05)。治疗3个月,两组肺功能指标用力肺活量(FVC)、最大呼气流量(PEF)、1秒用力呼气容积(FEV1)水平与治疗前相比均呈上升趋势,而免疫功能指标血清免疫球蛋白E(IgE)水平呈下降趋势,差异有统计学意义(P<0.05);且联合组治疗3个月与同期对照组相比,FVC、PEF、FEV1水平更高,而IgE水平更低,差异有统计学意义(P<0.05)。联合组和对照组治疗期间不良反应发生率分别为(9.84%)、(6.78%),差异无统计学意义(P>0.05)。结论:细菌溶解产物胶囊联合孟鲁司特治疗小儿支气管哮喘能提高治疗疗效,有效改善患者肺功能并降低炎症因子水平,且安全性良好。
Objective:To investigate the curative effect of bacterial lysate capsules combined with montelukast in the treatment of children with bronchial asthma and its effect on lung function.Method:A total of 120 children with bronchial asthma admitted to Yubei District People's Hospital of Chongqing from January 2021 to January 2024 were selected as the study objects and divided into two groups according to envelope randomized method,including control group(n=59,treated with montelukast)and combination group(n=61,treated with bacterial dissolved product capsules combined with montelukast).The clinical therapeutic effect and safety evaluation were compared between the two groups.Result:The proportion of obvious,effective and ineffective treatment in the combination group was(22.95%),(67.21%)and(9.84%),and that in the control group was(13.56%),(62.71%)and(23.73%),respectively.The total effective rate of the combined group was higher than that of the control group,and the difference was statistically significant(P<0.05).After 3 months of treatment,the levels of forced vital capacity(FVC),maximum expiratory flow(PEF)and forced expiratory volume in 1 second(FEV1)of lung function indexes in 2 groups were increased compared with before treatment,while the levels of serum immunoglobulin E(IgE)of immune function indexes were decreased,with statistical significance(P<0.05).After 3 months of treatment,compared with the control group,the levels of FVC,PEF and FEV1 in combination group were higher,while IgE levels were lower,with statistical significance(P<0.05).The incidence of adverse reactions in combination group and control group was 9.84%and 6.78%,respectively,with no statistical significance(P>0.05).Conclusion:Bacteriolysis capsules combined with montelukast in the treatment of children with bronchial asthma can improve the therapeutic effect,effectively improve lung function and reduce the level of inflammatory factors,with good safety.
作者
杜芳
顾艳红
何益春
DU Fang;GU Yanhong;HE Yichun(Yubei District People's Hospital,Chongqing 401120,China;不详)
出处
《中外医学研究》
2025年第18期39-42,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
基金
重庆市渝北区人民医院2023年院级医学科研项目(ybyk2023-19)。
关键词
小儿支气管哮喘
细菌溶解产物
孟鲁司特
疗效
肺功能
Children bronchial asthmatic
Bacterial lysates
Montelukast
Therapeutic effect
Pulmonary function
