摘要
目的探讨双水平气道正压(BiPAP)无创通气对老年肺癌合并心力衰竭患者心肌损伤标志物及心肺功能的影响。方法选择老年肺癌合并心力衰竭患者86例,采用随机数字表法将患者分为观察组(n=43)与对照组(n=43)。对照组予以常规综合干预,基于此,观察组加用BiPAP无创通气。比较2组治疗效果、心肌损伤标志物水平及心功能[心率(HR)、左心室射血分数(LVEF)]、肺功能[呼吸频率(RR)、第1秒用力呼气量(FEV1)]。结果观察组治疗总有效率优于对照组,差异有统计学意义(P<0.05)。2组治疗前心肌损伤标志物水平、心肺功能比较,差异无统计学意义(P>0.05);2组治疗后心肌损伤标志物水平、HR、RR均降低,LVEF、FEV1均升高,且观察组变化更明显,差异有统计学意义(P<0.05)。结论对老年肺癌合并心力衰竭患者采用BiPAP无创通气干预有利于减轻心肌损伤,改善心肺功能,提升治疗效果,值得临床广泛应用。
Objective To investigate the effect of noninvasive ventilation on myocardial injury markers and cardiopulmonary function in elderly patients with lung cancer and heart failure.Methods 86 elderly patients with lung cancer and heart failure were selected and divided into observation group(n=43)and control group(n=43)by random number table.The control group received routine comprehensive intervention,based on this,the observation group added BiPAP noninvasive ventilation.The treatment effect,markers of myocardial injury and cardiac function[heart rate(HR),left ventricular ejection fraction(LVEF)],pulmonary function[respiratory rate(RR),forced expiratory volume at 1 second(FEV 1)]indicators were compared in group 2.Results The overall response rate in the observation group was better than the control group,statistically significant(P<0.05).No differences were found between myocardial injury markers and cardiopulmonary function markers(P>0.05),which decreased myocardial injury markers,HR,and RR,and the changes were more significant(P<0.05).Conclusion Non-invasive ventilation intervention with BiPAP in elderly patients with lung cancer and heart failure is beneficial to reducing myocardial injury,improving cardiopulmonary function and improving therapeutic effect,which is worth wide clinical application.
作者
李露露
LI Lulu(Zhengzhou Yihe Hospital,Zhengzhou,450000)
出处
《实用癌症杂志》
2025年第4期670-672,共3页
The Practical Journal of Cancer
关键词
老年肺癌
心力衰竭
BIPAP无创通气
心肌损伤标志物
心肺功能
Elderly lung cancer
Heart failure
BiPAP non-invasive ventilation
Myocardial injury markers
Cardiopulmonary function
