摘要
皮质类固醇激素是慢性鼻窦炎伴鼻息肉(CRSwNP)术后最常用的药物治疗。虽然局部使用皮质类固醇可有效减轻与慢性鼻窦炎(CRS)相关的症状,且减少全身副作用,但其在鼻腔内的分布是有限的,主要依赖于其释放介质。皮质类固醇药物洗脱支架是一种相对新颖的技术,可以将高浓度的皮质类固醇直接且持续地释放至鼻窦黏膜上。目前,药物支架最常用于CRS患者的内镜鼻窦手术(ESS)的术中和术后,可显著改善黏膜炎症及术后症状,并降低鼻息肉的复发。本文综述了两种类固醇药物洗脱支架的临床疗效及安全性证据,药物支架结合其他局部给药方式可以得到更好的药物分布,为术中及术后联合用药提供思路。
Corticosteroids are the commonly used drug therapy for chronic rhinosinusitis with nasal polyps(CRSwNP)after surgery.While topical corticosteroids effectively reduce the symptom associated with CRS and systemic side effects,their distribution inside the nasal cavity is limited and primarily dependent on the release of mediators.Corticosteroid eluting stents serve as a relatively novel technology that can deliver high concentrations of corticosteroids directly and continuously onto the sinus mucosa.At present,drug implant for CRS are most commonly used during and after endoscopic sinus surgery(ESS),which are beneficial to improve mucosal inflammation burden and postoperative symptoms,and reduce the recurrence of nasal polyps.This paper reviews the clinical efficacy and safety evidence of two corticosteroid eluting stents.Drug stents combined with other topical drug administration can give better drug distribution and provide ideas for intraoperative and postoperative combined drug use.
作者
张泽宇
柴向斌
ZHANG Zeyu;CHAI Xiangbin(Shanxi Medical University,Taiyuan 030000,China;Department of Otolaryngology Head and Neck Surgery,the First Hospital of Shanxi Medical University,Taiyuan 030000,China)
出处
《中国耳鼻咽喉颅底外科杂志》
2025年第1期42-45,共4页
Chinese Journal of Otorhinolaryngology-skull Base Surgery
