摘要
近十年来,高通量测序技术提供了海量的基因组突变数据,对肿瘤样本突变数据的解析显示出与致癌因素密切相关的突变特征,称为"突变签名",可用来分析肿瘤多阶段发展过程中各类致癌因素的贡献度。电离辐射诱导的基因突变是其致癌效应的分子基础,阐明电离辐射诱导的突变签名的规律,对于深入理解随机性效应具有重要意义。本文介绍了突变签名的研究历史与分析方法,全面总结了目前电离辐射诱导的突变签名的研究现状,并展望了该领域的发展。
In the past decade,high-throughput sequencing technologies have generated a massive amount of genomic mutation data.The interpretation of mutation data from tumor samples has revealed mutational features highly associated with carcinogenic factors,which are referred to as mutational signatures.These mutational signatures enable the assessment of the contribution rates of various carcinogenic factors during the multi-stage development of tumors.Ionizing radiation-induced gene mutations constitute the molecular basis for its carcinogenic effects.Clarifying the patterns of mutational signatures induced by ionizing radiation is of great importance for a profound understanding of stochastic effects.This review presents the research history and analytical method of mutational signatures as well as a comprehensive summary of the current status of research on mutational signatures induced by ionizing radiation.The future development of this field is also discussed.
作者
王婷
俞苏桐
李婕
郭怡含
俞家华
Wang Ting;Yu Sutong;Li Jie;Guo Yihan;Yu Jiahua(School of Radiation Medicine and Protection of Soochow University,State Key Laboratory of Radiation Medicine and Protection,Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions,Suzhou 215123,China)
出处
《中华放射医学与防护杂志》
CAS
CSCD
北大核心
2024年第7期628-632,共5页
Chinese Journal of Radiological Medicine and Protection
基金
国家自然科学基金(82273583)。
关键词
电离辐射
突变
突变签名
肿瘤
Ionizing radiation
Mutation
Mutational signature
Tumor
