摘要
目的探讨卡麦角林与神经内镜下经鼻蝶窦垂体瘤切除术联用对老年垂体瘤患者的治疗效果及对泌乳素(PRL)、促肾上腺皮质激素(ACTh)、生长激素(HGH)的影响。方法选取2020-05—2023-05运城市中心医院收治的老年垂体瘤患者82例,随机分为对照组41例,研究组41例。对照组采用神经内镜下经鼻蝶入路手术治疗,研究组在此基础上加用卡麦角林。比较2组总有效率、激素水平、炎症因子指标、生活质量评分及治疗安全性。结果研究组总有效率(92.68%)较对照组(75.61%)更高(P<0.05)。2组患者的激素水平均有明显改善,研究组PRL、ACTH、HGH水平显著低于对照组(P<0.05)。2组治疗后炎症因子水平均下降,研究组基质金属蛋白酶2(MMP-2)、Xklp2靶蛋白(TPX2)、P53蛋白水平显著低于对照组(P<0.05)。治疗后2组患者的生活质量均明显改善,研究组生活质量量表(SF-36)评分显著高于对照组(P<0.05)。2组治疗安全性无统计学差异(P>0.05)。结论对老年垂体瘤患者采用神经内镜下经典术式与卡麦角林联合治疗,可有效提高患者的生活质量,减轻炎症反应,效果较为理想,临床应用价值较高。
Objective To investigate the therapeutic effect of the combination of cabergoline and endonasal transsphenoidal pituitary tumors resection in elderly patients with pituitary tumors,and its impacts on prolactin(PRL),adrenocorticotropin(ACTh),and human growth hormone(HGH).Methods From May 2020 to May 2023,82 elderly patients with pituitary tumors admitted to Yuncheng Central Hospital were randomly separated into the control group of 41 cases and the study group of 41 cases.The control group received endonasal transsphenoidal approach surgery,while the study group received additional treatment with cabergoline on this basis.The total effective rate,hormone levels,inflammatory factor indicators,quality of life scores,and treatment safety of the two groups were compared.Results The total effective rate of the study group(92.68%)was significantly higher than that of the control group(75.61%,P<0.05).The levels of PRL,ACTH and HGH in the study group were significantly lower than those in the control group(P<0.05),inflammatory factors in both groups were decreased after treatment,and the levels of matrix metalloproteinase 2(MMP-2),Xklp2 target protein(TPX2)and P53 protein in the study group were significantly lower than those in the control group(P<0.05).After treatment,the quality of life in both groups was significantly improved,and the score of SF-36 in the study group was significantly higher than that in the control group(P<0.05).There was no obvious difference in safety between the two groups(P>0.05).Conclusion The classic neuroendoscopic surgery combined with cabergoline for elderly patients with pituitary tumors can effectively improve their quality of life,reduce inflammatory reactions,and achieve ideal results.The clinical application value is high.
作者
王磊
周新管
WANG Lei;ZHOU Xinguan(Yuncheng Central Hospital,Yuncheng 044000,China)
出处
《中国实用神经疾病杂志》
2024年第7期837-842,共6页
Chinese Journal of Practical Nervous Diseases
基金
山西省科学技术项目(编号:200619)。
关键词
垂体瘤
经鼻蝶窦入路切除术
神经内镜
卡麦角林
泌乳素
促肾上腺皮质激素
生长激素
Pituitary tumors
Nasal transsphenoidal approach resection
Neuroendoscopy
Cabergoline
Prolactin
Adrenocorticotropin
Human growth hormone
