摘要
目的:研究亚胺培南西司他丁钠与美罗培南治疗重症细菌感染的效果。方法:选取2017年3月—2020年11月鲁山县人民医院收治的86例重症细菌感染患者作为研究对象,按随机数表法分为对照组和实验组,每组各43例。对照组予以美罗培南治疗,实验组予以亚胺培南西司他丁钠治疗。对比两组患者疗效、恢复相关时间、病原菌清除率、不良反应发生率及治疗前、治疗2个疗程后血清炎性因子[白细胞介素-6 (IL-6)、肿瘤坏死因子-α(TNF-α)]水平。结果:实验组总有效率为93.02%,高于对照组的76.74%,差异有统计学意义(χ^(2)=4.441,P<0.05);实验组入住ICU时间、白细胞计数恢复正常时间、发热消退时间均短于对照组,差异有统计学意义(t=3.429、2.273、3.240,P<0.05);实验组病原菌清除率为90.70%,高于对照组的74.42%,差异有统计学意义(χ^(2)=3.957,P<0.05);治疗2个疗程后,实验组血清IL-6、TNF-α水平均低于对照组,差异有统计学意义(t=12.437、9.113,P<0.05);两组患者不良反应发生率比较,差异无统计学意义(χ^(2)=0.001,P>0.05)。结论:与美罗培南相比,亚胺培南西司他丁钠应用于重症细菌感染患者临床治疗中,可提高疗效和病原菌清除率,减少临床症状恢复时间,减轻炎性反应发生情况,且不良反应发生率低。
Objective:To study the effect of imipenem cilastatin sodium and meropenem in the treatment of severe bacterial infection.Methods:A total of 86 patients with severe bacterial infection who were admitted to the hospital from March 2017 to November 2020 were selected as the research objects,and divided into control group and experimental group according to the random number table method,with 43 cases in each group.The control group was treated with meropenem and the experimental group was treated with imipenem cilastatin sodium.The curative effect,recovery related time,pathogen clearance rate,incidence of adverse reactions and serum inflammatory factor levels (interleukin-6[IL-6]and tumor necrosis factor-α[TNF-α]) before and after treatment were compared between the two groups.Results:The total effective rate in the experimental group was 93.02%,higher than76.74%in the control group,and the difference was statistically significant (χ^(2)=4.441,P<0.05).The time of staying in ICU,the time of white blood cell count returning to normal,and the time of fever subsidence in the experimental group were all shorter than those in the control group,and the differences were statistically significant (t=3.429,2.273,3.240,P<0.05).The clearance rate of pathogenic bacteria in the experimental group (90.70%) was higher than that in the control group (74.42%),and the difference was statistically significant (χ^(2)=3.957,P<0.05).After 2 courses of treatment,the levels of serum IL-6 and TNF-α in the experimental group were lower than those in the control group,and the difference was statistically significant (t=12.437,9.113,P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups (χ^(2)=0.001,P>0.05).Conclusion:Compared with meropenem,imipenem cilastatin sodium in the clinical treatment of patients with severe bacterial infection can improve the curative effect and pathogen clearance,the recovery time of clinical symptoms,reduce inflammatory reactions,and the incidence of adverse reactions is low.
作者
李恒杰
LI Heng-jie(Department of Pharmacy,Lushan County People’s Hospital,Pingdingshan,Henan,467300,China)
出处
《黑龙江医学》
2022年第16期1978-1980,共3页
Heilongjiang Medical Journal
基金
河南省自然科学研究计划项目(142102310139)。
