摘要
非编码RNA(ncRNA)是一类具有多种生物学功能但不能翻译蛋白质的RNA。葡萄膜炎是常见的致盲眼病,易反复发作且治疗棘手,其发病机制尚不完全清楚。近年来研究表明,ncRNA在人类葡萄膜炎和实验性自身免疫性葡萄膜炎发病过程中有着重要的调控作用,可通过调节与免疫相关的重要信号通路、T淋巴细胞或抗原提呈细胞的免疫应答及炎性因子分泌等方式参与葡萄膜炎发病过程,靶向某些ncRNA对葡萄膜炎的治疗具有一定意义。此外,ncRNA的单核苷酸多态性及拷贝数变异与葡萄膜炎的遗传易感性高度相关。因此,ncRNA可能作为葡萄炎诊断、判断病情及预后的生物标志物,靶向ncRNA可能成为治疗葡萄膜炎的新策略。本文主要对微小RNA和长链非编码RNA在葡萄膜炎发病中的调控作用进行综述。
Non-coding RNA(ncRNA)is a type of RNA that has multiple biological functions but is not translated into proteins.Uveitis,a common blindness-causing disease,is susceptible to relapse and difficult to treat,but its pathogenesis is not completely elucidated.Recent studies have shown that ncRNA plays an important role in the pathogenesis of human uveitis and rabbit experimental autoimmune uveitis.ncRNAs participate in the pathogenesis of uveitis by regulating important signaling pathways related to immunity,the immune response of T lymphocytes or antigen-presenting cells,and the secretion of inflammatory factors,so targeting some ncRNAs is of certain value for the treatment of uveitis.The single nucleotide polymorphisms and copy number variation of ncRNA are highly correlated with the genetic susceptibility of uveitis.Therefore,ncRNA may become a biomarker for the diagnosis and prognosis of uveitis and targeting ncRNA may become a new treatment strategy in uveitis.The regulatory roles of microRNA and long non-coding RNA in the pathogenesis of uveitis were reviewed in this article.
作者
李冰(综述)
杨付花
张晓敏(审校)
Li Bing;Yang Fuhua;Zhang Xiaomin(Tianjin Key Laboratory of Retinal Functions and Diseases,Tianjin Branch of National Clinical Research Center for Ocular Disease,Eye Institute and School of Optometry,Tianjin Medical University Eye Hospital,Tianjin 300384,China)
出处
《中华实验眼科杂志》
CAS
CSCD
北大核心
2022年第8期775-780,共6页
Chinese Journal Of Experimental Ophthalmology
基金
国家自然科学基金项目(82171042、81870651)
天津市科技支撑重点项目(20YFZCSY00990)
天津市自然科学基金重点项目(20JCZDJC00100)
天津市医学重点学科(专科)建设项目(TJYXZDXK-037A)
天津市教委科研计划项目(2020KJ178)。
