摘要
目的研究妊娠期女性生殖道感染病原菌分布情况及耐药性。方法选取376例生殖道感染的妊娠期女性,均进行细菌培养及药敏检测,分析女性生殖道感染的病原菌分布情况及药敏结果。结果376例女性中,念珠菌、支原体、加德纳菌、滴虫、链球菌属、葡萄球菌、大肠杆菌、淋球菌的感染例数依次为215、195、92、47、13、8、6、1例,可见存在合并感染。其中念珠菌、支原体的感染率最高,依次为57.18%(215/376)、51.86%(195/376);淋球菌的感染率最低,为0.27%(1/376)。念珠菌对两性霉素B和氟胞嘧啶、氟康唑敏感率较高,依次为98.60%(212/215)、95.81%(206/215)、93.95%(202/215);念珠菌对伊曲康唑的耐药率最高,为87.91%(189/215)。支原体对氧氟沙星、阿奇霉素、环丙沙星耐药率较高,依次为43.59%、40.00%、29.23%;对交沙霉素、美满霉素、强力霉素、克拉霉素、壮观霉素敏感率较高,依次为100.00%、99.49%、98.97%、98.46%、82.05%,可对临床治疗支原体提供有力依据。结论女性生殖道中具有许多感染菌种类,且其总的耐药性较高,临床中需要参照病原学、药敏等方面的结果,更具针对性地应用抗菌类药物。
Objective To study the distribution and drug resistance of pathogen infection of female reproductive tract during pregnancy.Methods 376 pregnant women with reproductive tract infection were selected for bacterial culture and drug susceptibility detection,so that the distribution and drug susceptibility of pathogen infection of female reproductive tract were analyzed.Results Among 376 women,the number of cases infected with Candida,Mycoplasma,Gardnerella,Trichomonas,Streptococcus,Staphylococcus,Escherichia coli and Neisseria gonorrhoeae were 215,195,92,47,13,8,6 and 1,respectively.Thus,it can be seen that there were coinfection cases.The infection rates of Candida and Mycoplasma were the top two,which were 57.18%(215/376),51.86%(195/376);while the Neisseria gonorrhoeae had the lowest infection rate of 0.27%(1/376).The susceptibility rates of Candida to amphotericin B,flucytosine and fluconazole were relatively high,which were 98.60%(212/215),95.81%(206/215)and 93.95%(202/215),respectively.Candida had the highest drug resistance rate to itraconazole,which was 87.91%(189/215).The drug resistance rates of Mycoplasma to ofloxacin,azithromycin and ciprofloxacin were 43.59%,40.00%and 29.23%respectively;while the susceptibility rates of Mycoplasma to josamycin,minocycline,doxycycline,clarithromycin and spectinomycin were 100.00%,99.49%,98.97%,98.46%and 82.05%,respectively.The results might provide a strong basis for the clinical treatment of Mycoplasma.Conclusion There are many kinds of infectious bacteria in female reproductive tract,and their overall drug resistance is high,so it is necessary to use antimicrobial drugs based on the results of etiology and drug susceptibility in clinical practice.
作者
孙晓娟
SUN Xiao-juan(Shenyang Maternity and Infant Hospital,Shenyang 110011,China)
出处
《中国实用医药》
2022年第3期93-95,共3页
China Practical Medicine
关键词
病原菌感染
女性生殖道
抗菌药物
念珠菌
支原体
耐药
Pathogen infection
Female genital tract
Antibiotics
Candida
Mycoplasma
Drug resistance
