摘要
目的:探讨乙酰谷酰胺联合依达拉奉治脑梗死的疗效和作用机制。方法:2019年1-12月收治脑梗死患者120例,随机分为两组,各60例。对照组行乙酰谷酰胺治疗;观察组行乙酰谷酰胺联合依达拉奉治疗。比较两组血清神经元特异性烯醇化酶(NSE)、血清S100β蛋白水平、肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)及C反应蛋白(CRP)等指标水平及神经功能评分(NIHSS)及临床疗效。结果:观察组治疗后NSE、S100β、TNF-α、IL-6、CRP水平和NIHSS评分均低于对照组,差异有统计学意义(P<0.05);观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。结论:乙酰谷酰胺联合依达拉奉对脑梗死疗效确切。
Objective:To investigate the efficacy and mechanism of aceglutamide combined with edaravone in the treatment of cerebral infarction.Methods:From January to December 2019,120 patients with cerebral infarction were selected,they were randomly divided into the two groups with 60 cases in each group.The control group was treated with aceglutamide.The observation group was treated with aceglutamide combined with edaravone.The levels of serum neuron specific enolase(NSE),serum S100βprotein,tumor necrosis factorα(TNF-α),interleukin 6(IL-6)and C reactive protein(CRP),neurological function score(NIHSS)and clinical efficacy were compared between the two groups.Results:After treatment,the levels of NSE,S100β,TNF-α,IL-6,CRP and NIHSS in the observation group were significantly lower than those in the control group,the differences were statistically significant(P<0.05).The total effective rate in the observation group was significantly higher than that in the control group,the difference was statistically significant(P<0.05).Conclusion:Aceglutamide combined with edaravone is effective in the treatment of cerebral infarction.
作者
杨泽威
廖侃华
刘杰
陈少辉
杨金珠
Yang Zewei;Liao Kanhua;Liu Jie;Chen Shaohui;Yang Jinzhu(The First Department of Rehabilitation,Traditional Chinese Medicine Hospital of Yangchun City,Guangdong Yangjiang 529600)
出处
《中国社区医师》
2021年第2期74-75,共2页
Chinese Community Doctors
关键词
乙酰谷酰胺
依达拉奉
脑梗死
作用机制
神经功能
Aceglutamide
Edaravone
Cerebral infarction
Mechanism of action
Neurological function
