摘要
目的探讨中药联合针刺在宫腔内人工授精促排卵周期的应用效果。方法选取2018年1~12月就诊于南平人民医院生殖中心符合夫精人工授精适应症的84例宫腔内人工授精患者(共128个促排卵周期)作为研究对象,按照随机数字表法将其分为对照组(42例,62个促排卵周期)和观察组(42例,66个促排卵周期)。对照组采用枸橼酸氯米芬/来曲唑/注射用尿促卵泡素+人绒毛膜促性腺激素(HCG)+宫腔内人工授精,观察组在对照组治疗的基础上加用中药联合针刺。观察两组HCG日血清促黄体生成素(LH)及雌二醇(E2)值,比较两组的子宫内膜分型、子宫内膜厚度及妊娠情况。结果两组患者HCG日血清LH、E2值比较,差异无统计学意义(P>0.05)。观察组患者的子宫内膜类型优于对照组,子宫内膜厚度值高于对照组,差异有统计学意义(P<0.05)。观察组患者的未破裂卵泡黄素化综合征发生率低于对照组,差异有统计学意义(P<0.05)。两组患者的宫内妊娠、自然流产、异位妊娠发生率比较,差异无统计学意义(P>0.05)。结论中药联合针刺疗法可改善宫腔内人工授精促排卵周期的子宫内膜类型及厚度,降低未破裂卵泡黄素化综合征发生率,值得推广。
Objective To investigate the application effect of traditional Chinese medicine combined with acupuncture on ovulation induction cycle in intrauterine insemination.Methods A total of 84 patients with intrauterine insemination(128 ovulation induction cycles in total)admitted to the Reproductive Center of Nanping People′s Hospital from January to December 2018 were selected as the research objects,and were divided into control group(42 cases,62 ovulation induction cycles)and observation group(42 cases,66 ovulation induction cycles)according to the random number table method.The control group was treated with Clomiphene Citrate/Letrozole/injection of Urinary Follicle-Stimulating Hormone+human chorionic gonadotropin(HCG)+intrauterine insemination.On the basis of treatment in the control group,the observation group was added with traditional Chinese medicine combined with acupuncture.The serum luteinizing hormone(LH)and estradiol(E2)values of the two groups were observed on HCG day,and the endometrial typing,endometrial thickness and pregnancy status of the two groups were compared.Results There were no significant differences in serum LH and E2 on HCG day between the two groups(P>0.05).The endometrial type in the observation group was better than that in the control group,and the endometrial thickness was higher than that in the control group,with statistically significant differences(P<0.05).The incidence of luteinized unruptured follicle syndrome in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).The incidence rates of intrauterine pregnancy,spontaneous abortion and ectopic pregnancy were compared between the two groups,and the differences were not statistically significant(P>0.05).Conclusion Traditional Chinese medicine combined with acupuncture therapy can improve the type and thickness of endometrium,reduce the incidence of luteinized unruptured follicle syndrome,which is worthy of promotion.
作者
王英
潘丽贞
陈弦
WANG Ying;PAN Li-zhen;CHEN Xian(Department of Obstetrics and Gynecology,Nanping People′s Hospital Affiliated to Fujian University of Traditional Chinese Medicine,Fujian Province,Nanping353000,China)
出处
《中国当代医药》
2020年第36期159-162,共4页
China Modern Medicine
关键词
宫腔内人工授精
促排卵周期
针刺
子宫内膜
妊娠
Intrauterine insemination
Ovulation induction cycle
Acupuncture
Endometrium
Pregnancy
