摘要
目的:研究香砂养胃颗粒和小儿清解颗粒挥发性成分,为产品质量的稳定性和一致性评价提供方法。方法:采用气相色谱-质谱联用分析技术,分析香砂养胃颗粒和小儿清解颗粒中的挥发性成分,并对2个品种大生产批次间及实验室提取挥发油化学成分进行对比分析。结果:香砂养胃颗粒挥发油中共鉴别出24种成分,主要以烯烃、醇类、酮类为主;小儿清解颗粒挥发油中共鉴别出22种成分,主要以烯烃、醇类、醛类为主,大生产与实验室提取挥发油各化学成分基本保持一致,相对含量有一定差别。结论:明确了大生产与实验室提取挥发油的差异,为2种中成药生产的质量控制提供了有效的方法。
Objective:To study the chemical components of volatile oil extracted from Xiangsha Yangwei Granules and Xiaoer Qingjie Granules in order to provide the method for evaluation of the stability and consistence of product quality.Methods:The chemical components of volatile oil extracted from Xiangsha Yangwei Granules and Xiaoer Qingjie Granules were analyzed by GC-MS,and the chemical composition of volatile oil in multiple batches extracted in commercial manufacture and laboratory were compared.Results:A total of 24 components,mainly including olefins,alcohols,and ketones,were identified in the volatile oil of Xiangsha Yangwei Granules.A total of 22 components,mainly including olefins,alcohols and aldehydes,were identified in the volatile oil of Xiaoer Qingjie Granules.The chemical compositions of volatile oil extracted in commercial manufacture and laboratory were basically consistent,but the relative contents had some differences.Conclusion:The differences of volatile oil extracted in commercial manufactureand laboratory are described.That provides the effective method for quality control of two varieties of Chinese patent medicines.
作者
王淑英
张荣寰
李铮
李晚婧
张润
姚璐
WANG Shuying;ZHANG Ronghuan;LI Zheng;LI Wanjing;ZHANG Run;YAO Lu(Beijing Tongrentang Technologies Co.Ltd.,Beijing 100079,China;Beijing Tongrentang Co.Ltd.,Beijing 100079,China)
出处
《中国药品标准》
CAS
2019年第6期537-543,共7页
Drug Standards of China
基金
北京市科技计划课题“G20龙头企业培育—中药浓缩及挥发油提取关键技术研究”(Z151100003815010)
关键词
中成药
挥发油
GC-MS
化学成分
质量评价
Chinese patent medicine
volatile oil
GC-MS
chemical composition
quality evaluation
