摘要
粪菌移植(fecal microbiota transplantation,FMT)是将健康人肠道菌群移植至病人的胃肠道内,以重建具有正常功能的肠道菌群,从而达到治疗疾病的目的。近年来粪菌移植越来越受到关注,其在治疗炎症性肠病、自身免疫性疾病、肠易激综合征、代谢综合征疾病方面取得了重要进展。肠道作为人体重要的消化器官,同时也具有着复杂的免疫功能,正常肠道菌群在促进免疫系统发育,维持正常免疫功能,协同抵抗病原菌入侵方面,发挥着重要作用,而粪菌移植通过重建患者已紊乱的肠道菌群,也对机体免疫功能产生影响。该文就粪菌移植对肠道免疫系统的影响研究进展进行综述。
Fecal microbiota transplantation(FMT)is a treatment of transplanting a healthy human intestinal flora to the patient′s gastrointestinal tract, in order to treat diseases by reconstructing the normal function of the intestinal flora.In recent years, fecal microbiota transplantation attracted more attention since many studies have demonstrated that fecal microbiota transplantation has great clinical value in the treatment of inflammatory bowel disease, autoimmune disease, irritable bowel syndrome, metabolic syndrome and other diseases.Intestinal tract which is an important human intestinal digestive organ has complex immune functions.Normal intestinal flora plays an important role in promoting the development of the immune system, maintaining normal immune function, and synergistically antagonizing pathogens.The fecal microbiota transplantation affects the receptor′s immune function by reconstructing disorganized intestinal flora.In this paper, the effect of fecal microbiota transplantation on the intestinal immune system is reviewed.
作者
尹瀚浚(综述)
刘志峰(审校)
Yin Hanjun;Liu Zhifeng(Department of Gastroenterology, the Affiliated Children′s Hospital of Nanjing Medical University, Nanjing 210000, China)
出处
《国际儿科学杂志》
2019年第4期263-267,共5页
International Journal of Pediatrics
关键词
粪菌移植
菌群
免疫
Fecal microbiota transplantation
Flora
Immune
