摘要
肿瘤细胞即使在有氧环境下也选择糖酵解作为主要合成ATP的方式,称为有氧糖酵解(Warburg Effect)。这种能量底物消耗大而供能少的特殊代谢方式导致不可逆的肿瘤恶病质。肿瘤恶病质的主要表现是骨骼肌损耗、脂肪褐化以及肝脏Cori循环过度激活。乳酸是肿瘤有氧糖酵解的代谢产物,同时参与调节肿瘤生长,最终导致肿瘤恶病质发生。尽管运动有比较广泛的抗肿瘤积极作用,但运动引起乳酸生成增加、肌肉蛋白质分解加强、脂肪组织褐化、肝脏Cori循环加强等却属于正常生理应激,这与肿瘤恶病质的防御存在矛盾。运动引起正常生理应激与肿瘤恶病质的病理表现意义决然不同,运动参与可能打破肿瘤异常代谢,抑制肿瘤发生。对有氧糖酵解的细胞信号调控以及运动抗肿瘤的这些矛盾进行阐述,推测肿瘤有氧糖酵解状态下与正常生理状态下的运动应激反应可能存在巨大差异,运动应激引起机体的生理反应可能是运动抗肿瘤的机制。
Glycolysis is the primary pathway for ATP synthesis in tumor cells even in aerobic status,this process is called aerobic glycolysis(Warburg Effect).The aerobic glycolysis consumes more substrates but generates less energy,which leading to irreversible cancer cachexia.Cancer cachexia is characterized as skeletal muscle wasting,white adipose browning,and liver Cori cycle overactivation.As a metabolite during tumor aerobic glycolysis,lactate is involved in regulating the growth of tumor simultaneously,which contributing to cancer cachexia ultimately.Exercise has extensive positive effects on anti-tumor,however,the increase of lactate level,muscle protein catabolism,adipose tissue browning and liver Cori cycle over-activating are contradictory with the defense of cancer cachexia from exercise.Exercise-induced physiological stress is substantially different from the pathological manifestations of cancer cachexia,which can inhibit tumorigenesis by breaking the tumor abnormal metabolism.In this review,the cell signal regulation of aerobic glycolysis and the contradictions in exercise anti-tumor are discussed.It is speculated that the response of exercise stress in tumor cells varies from it in normal cells,exercise-induced physiological stressis the possible mechanism forexercise anti-tumor.
作者
曹露
漆正堂
丁树哲
CAO Lu;QI Zhengtang;DING Shuzhe(Key Laboratory of Adolescent Health Assessment and Exercise Intervention of Ministry of Education,East China Normal University,Shanghai 200241,China;School of Physical Education and Health Care,East China Normal University,Shanghai 200241,China)
出处
《体育科学》
CSSCI
北大核心
2019年第2期73-82,F0003,共11页
China Sport Science
基金
国家自然科学基金项目(31671241)
