摘要
血管性认知障碍(VCI)作为继阿尔茨海默病后最常见的认知障碍,导致家庭与社会负担日益加重。其危险因素包括年龄、高血压、血脂代谢异常、糖尿病、同型半胱氨酸升高等。而脂蛋白为血浆中常见的生化指标,其与动脉粥样硬化所致的VCI密切相关。不同的脂蛋白组分对VCI产生不同的影响。其中,低密度脂蛋白、载脂蛋白B与高密度脂蛋白对VCI的发生发展起独特作用。因此,早期发现及干预VCI的可控制性危险因素对VCI的预防和治疗具有重要意义。
Vascular cognitive impairment(VCI),as the most common cognitive impairment after Alzhimer′s disease,results in increasing burden on family and society.Risk factors for VCI include age,hypertension,dyslipidemia,diabetes,and hyperhomocysteinemia.Furthermore,lipoprotein is a common biochemical index in plasma,which is closely related to VCI caused by atherosclerosis.Different lipoproteins have different effects on VCI,of which,low density lipoprotein,apolipoprotein B and high density lipoprotein have played unique roles in the development of VCI.Therefore,early detection and intervention of controllable risk factors is of great significance for the prevention and treatment of VCI.
作者
廖子蔚
程利萍
李晓雪
王莎
霍瑞民
LIAO Ziwei;CHENG Liping;LI Xiaoxue;WANG Sha;HUO Ruimin(Department Two of Neurology,Handan First Hospital,Handan 056002,China)
出处
《医学综述》
2018年第24期4814-4818,共5页
Medical Recapitulate
基金
河北省医学科学研究重点课题(20181646)
关键词
血管性认知障碍
脂蛋白
相关性
Vascular cognitive impairment
Lipoproteins
Correlation
