摘要
目的探讨妊娠期糖尿病合并高血压患者不良妊娠结局的相关危险因素。方法选取我院2014年2月～2017年2月妊娠期糖尿病合并高血压患者80例,记录患者妊娠结局,根据有无不良妊娠结局分为不良妊娠结局组(30例)与无不良妊娠结局组(50例),比较两组年龄、孕前体质指数、孕期增重、确诊孕周、口服葡萄糖耐量试验、妊娠期高血压分度、文化程度、经济状况、孕产史、糖尿病家族史、高血压家族史、不良孕产史等临床资料。结果发生不良妊娠结局患者共30例,占37.5%,包括羊水过多3例、胎膜早破7例、早产10例、产后出血6例、巨大儿8例、低体重儿5例、新生儿窒息3例、新生儿低血糖3例;不良妊娠结局组年龄≥35岁、孕前体质指数≥25kg/m^2、孕期总增重过多、口服葡萄糖耐量试验3项异常、妊娠期高血压分度重度患者比例显著高于无不良妊娠结局组(P<0.05);确诊孕周、文化程度、经济状况、孕产史、糖尿病家族史、高血压家族史、不良孕史两组比较差异无统计学意义(P>0.05)。结论年龄、孕前体质指数、孕期总增重、口服葡萄糖耐量试验、妊娠期高血压分度等5个因素对妊娠期糖尿病合并高血压患者不良妊娠结局有显著影响。
Objective To study the related risk factors of adverse pregnancy outcomes in patients with gestational diabetes mellitus（GDM）and hypertension.Methods 80 patients with GDM and hypertension treated in our hospital during the period from February 2014 to February 2017 were selected as the subjects.The pregnancy outcomes were recorded.The patients were divided into adverse pregnancy outcome group and non-adverse pregnancy outcome group according to the occurrence of adverse pregnancy outcomes.The clinical data such as age,pre-pregnancy body mass index（BMI）,weight gain during pregnancy,gestational weeks of confirmed diagnosis,oral glucose tolerance test（OGTT）,grade of GDM,education level,economic status,history of pregnancy,family history of diabetes mellitus,family history of hypertension and history of adverse pregnancy.Results In 80 patients with GDM and hypertension,there were 30 patients with adverse pregnancy outcomes,accounting for 37.5%,including 3 cases of polyhydramnios,7 cases of premature rupture of membranes,10 cases of premature delivery,6 cases of postpartum hemorrhage,8 cases of macrosomia,5 cases of low birth weight infants,3 cases of neonatal asphyxia and 3 cases of low birth blood glucose.The proportions of patients who were or older than 35 years old,patients whose pre-pregnancy BMI was or larger than 25 kg/m^2,patients with excessive weight gain during pregnancy,patients with 3 abnormal indexes of OGTT and patients with severe GDM in the adverse pregnancy outcome group were significantly higher than those in the non-adverse pregnancy outcome group（P〈0.05）.There was no significant differences between the two groups in gestational weeks of confirmed diagnosis,education level,economic status,history of pregnancy,family history of diabetes mellitus,family history of hypertension and history of adverse pregnancy（P〉0.05）.Conclusion Age,pre-pregnancy BMI,total weight gain during pregnancy,OGTT and grade of GDM have obvious effect on adverse pregnancy outcomes in patients with GDM and hypertension.
作者
张静
唐国珍
谢江燕
吴君
谭春梅
潘燕
ZHANG Jing;TANG Guozhen;XIE Jiangyan;WU Jun;TAN Chunmei;PAN Yan(Department of Obstetrics and Gynecology,The First Affiliated Hospital of Chengdu Medical College,Chengdu 610500,China)
出处
《西部医学》
2018年第10期1500-1504,共5页
Medical Journal of West China
关键词
妊娠期糖尿病
妊娠期高血压
妊娠结局
危险因素
Gestational diabetes mellitus
Gestational hypertension
Pregnancy outcome
Risk factors
