摘要
血脑屏障的存在,导致药物不能有效到达靶部位发挥作用,极大地影响神经系统药物的发展和进步。纳米技术已被证明是用于脑靶向治疗的一种有效工具,尤其在脑肿瘤和神经退行性疾病中应用甚广。功能化纳米粒通过表面修饰等提高药物的顺应性,在药物原来的治疗基础上,达到更加精准的靶向性,高效率在靶部位聚集,起到治疗作用。本文主要综述功能化纳米粒及其功能化策略,总结了影响功能化纳米粒脑靶向运输的因素,同时对功能化的纳米粒在脑部疾病治疗中的优势和应用进行阐述,为其相关研究提供参考。
The existence of the blood-brain barrier results in the drug failing to reach the target site effectively and exerting a great influence on the development and progress of the nervous system drug.Nanotechnology has been proven to be an effective tool for brain-targeted therapy,especially in brain tumors and neurodegenerative diseases.The functionalized nanoparticles improve drug compliance through surface modification and the like, and on the basis of the original treatment of the drug,achieve more precise targeting and high efficiency of aggregation at the target site and play a therapeutic role.This paper reviewed the functional nanoparticles and their functionalization strategies,as well as the advantage and application in diagnosis and treatment of brain diseases.This review provided a reference for the study of the treatment of brain disease.
作者
张文君
信雪维
李宏
岳昌林
朱东亚
宋春晓
王淑静
ZHANG Wenjun;XIN Xuewei;LI Hong;YUE Changlin;ZHU Dongya;SONG Chunxiao;WANG Shujing(School of Pharmacy,Harbin University of Commerce,Harbin 150076,China;Zhejiang Jiuxu Pharmaceutical Co.,ltd Jinhua 321000,China;Nanjing Medical University,Nanjing 211166,China)
出处
《药学研究》
CAS
2018年第10期597-599,603,共4页
Journal of Pharmaceutical Research
基金
哈尔滨市科技创新人才研究专项基金(No.2017RAQXJ132)
关键词
纳米粒
功能化
脑靶向
脑部治疗
Nanoparticles
Functionalization
Brain targeting
Braintreatment
