摘要
目的分析对比利福喷丁与利福平治疗肺结核患者效果及对降钙素原的影响。方法选择该院2016年8月—2017年8月收治的98例肺结核患者为研究对象,以随机数字表法将其分为参照组和实验组,每组49例患者,给予参照组患者利福平治疗,给予实验组患者利福喷丁治疗,比较两组患者治疗效果、并发症发生情况以及降钙素原变化,分析对比利福喷丁与利福平治疗肺结核患者效果及对降钙素原的影响。结果两组患者对比后结果,治疗有效率(χ~2=8.294 7,P=0.000 0),治疗后降钙素原变化情况比较(t=479.111 7,P=0.000 0),治疗后并发症发生情况:皮疹(χ~2=9.910 1,P=0.001 6);肝功能异常(χ~2=6.681 8,P=0.010 0);白细胞减少(χ~2=7.900 1,P=0.004 9);胃肠道反应(χ~2=5.861 2,P=0.015 5)。参照组患者治疗有效率为79.59%,实验组患者治疗有效率97.96%,实验组患者出现皮疹、肝功能异常、白细胞减少、胃肠道反应数量分别为0例、10例、4例、6例,而参照组分别为9例、22例、15例、16例。参照组患者治疗后降钙素原为(3.54±0.05)μg/L,实验组患者治疗降钙素原为(0.05±0.01)μg/L,两组患者治疗有效率、并发症发生情况以及降钙素原变化在统计学上均优于参照组,差异有统计学意义(P<0.05)。结论对肺结核患者使用利福喷丁,更有利于患者康复,患者出现的不良反应率相对较低,值得推广使用。
Objective To analyze and compare the comparison of effect of rifapentini and rifampin in treatment of patients with pulmonary tuberculosis and effect on procalcitonin. Methods 98 cases of patients with pulmonary tuberculosis admitted and treated in our hospital from August 2016 to August 2017 were selected and randomly divided into two groups with 49 cases in each, the control group and the experimental group were respectively treated with rifampin and rifapentini, and the treatment effect, occurrence of complications and changes of procalcitonin were compared, and the effect of rifapentini and rifampin in treatment of patients with pulmonary tuberculosis and effect on procalcitonin were analyzed. Results The treatment effective rate was（χ^2=8.294 7, P =0.000 0）, after treatment, the difference in the change of procalcitonin between the two groups was（ t=479.111 7,P=0.000 0）, after treatment, in terms of occurrence of complications, rash（χ^2=9.910 1, P=0.001 6）; hepatic dysfunction（χ^2=6.681 8, P=0.010 0）; hypoleucocytosis（χ^2=7.900 1, P=0.004 9）; gastrointestinal reaction（χ^2=5.861 2, P=0.015 5）, and the treatment effective rate in the control group and in the experimental group was respectively 79.59% and 97.96%, and the occurrence number of cases with Rash, liver dysfunction, hypoleucocytosis, gastrointestinal reactions in the experimental group and in the control group were respectively 0 case, 10 cases, 4 cases, 6 cases and 9 cases, 22 cases, 15 cases, 16 cases, and the procalcitonin after treatment in the control group and in the experimental group was respectively（3.54±0.05）μg/L and（0.05±0.01）μg/L,and the treatment effective rate, occurrence of complications and changes of procalcitonin were better than those in the control group, and the differences were statistically significant（P〈0.05）. Conclusion The rifapentini in patients with pulmonary tuberculosis is more conductive to recovery of patients, and the adverse reaction rate of patients is relatively low, and it is worth promotion and application.
作者
刘玉红
LIU Yu-hong(Fourth Department of Internal Medicine,Bole Fifth Division Hospital,Bole,Xinjiang,833400 China)
出处
《系统医学》
2018年第13期55-57,共3页
Systems Medicine
关键词
利福喷丁
利福平
肺结核
治疗效果
降钙素原
Rifapentini
Rifampin
Pulmonary tuber-culosis
Treatment effect
Proealeitonin
