摘要
目的探讨选用雷贝拉唑、克拉霉素联合阿莫西林方案治疗胃溃疡的临床效果。方法将我院收治的80例胃溃疡患者按随机数字法分为观察组(n=40,克拉霉素、雷贝拉唑联合阿莫西林治疗)、对照组(n=40,克拉霉素、奥美拉唑联合阿莫西林治疗),比较两组的治疗效果。结果观察组治疗总有效率及Hp根治率均高于对照组(P<0.05)。治疗后,两组的IL-2水平均升高,IL-6及CRP水平均降低,且观察组的IL-2水平明显高于对照组,CRP及IL-6水平明显低于对照组(P<0.05)。观察组的不良反应总发生率明显低于对照组(P<0.05)。结论给予胃溃疡患者雷贝拉唑和克拉霉素联合阿莫西林疗法治疗,可有效提高炎症反应控制效果,总疗效及安全性均更理想。
Objective To explore the clinical effect of rabeprazole and clarithromycin combined with amoxicillin in the treatment of gastric ulcer. Methods Eighty cases of patients with gastric ulcer treated in our hospital were divided into observation group（n=40, treated with clarithromycin, rabeprazole and amoxicillin） and control group（n=40, treated with clarithromycin, omeprazole and amoxicillin）. The treatment effects of the two groups were compared. Results The total effective rate of treatment and Hp eradication rate in the observation group were higher than those in the control group（P〈0.05）. After treatment, the IL-2 levels in the two groups increased, the IL-6 and CRP levels decreased, and the IL-2 level in the observation group was significantly higher than that in the control group, and the levels of CRP and IL-6 were significantly lower than those in the control group（P〈0.05）. The total incidence of adverse reactions in the observation group was significantly lower than that in the control group（P〈0.05）. Conclusion Rabeprazole and clarithromycin combined with amoxicillin in the treatment of gastric ulcer can effectively improve the control effect of inflammatory response, and the total efficacy and safety are more ideal.
作者
张利云
郑百战
ZHANG Li-yun;ZHENG Bai-zhan(Xianyang Hospital of Yan＇an University, Xianyang 712000, China)
出处
《临床医学研究与实践》
2018年第14期21-22,共2页
Clinical Research and Practice
关键词
胃溃疡
克拉霉素
雷贝拉唑
阿莫西林
gastric ulcer
clarithromycin
rabeprazole
amoxicillin
