摘要
目的观察右美托咪定和曲马多预防吸脂术后寒战的临床效果。方法选择2014年5月~2016年9月ASAⅠ~Ⅱ级择期吸脂术80例,随机分为4组各20例,手术缝合时,D1组10分钟静脉泵注右美托咪定0.4μg/kg,D2组10分钟静脉泵注右美托咪定0.6μg/kg,T组10分钟静脉泵注曲马多1 mg/kg,N组10分钟静脉泵注等量(20 ml)生理盐水。记录术后自主呼吸恢复时间、苏醒时间、拔管时间、定向力恢复时间、寒战例数和不良反应等。结果 D2组呼吸恢复时间、苏醒时间和拔管时间长于其他3组[D1、D2、T、N组呼吸恢复时间(5.5±1.3)、(6.2±1.2)、(5.1±1.8)、(5.0±0.9)min,F=3.330,P=0.024;苏醒时间(10.2±1.3)、(11.5±1.5)、(9.7±2.7)、(9.5±1.8)min,F=4.429,P=0.006;拔管时间(12.9±1.5)、(14.2±1.6)、(12.8±2.4)、(12.7±1.9)min,F=2.845,P=0.043];4组中,N组术后寒战最多(3、2、3、9例,χ~2=9.188,P=0.027),T组恶心呕吐最多(2、1、8、4例,χ~2=9.436,P=0.024),D2组心动过缓最多(3、7、1、1例,χ~2=9.412,P=0.024)。结论泵注0.4μg/kg右美托咪定可降低吸脂术后寒战发生率,且不良反应发生率低。
bObjective To observe the efficiency and safety of dexmedetomidine and tramadol to prevent postoperative shivering after liposuction. Methods A total of 80 patients undergoing liposuction were randomly divided into 4 groups with 20 cases in each group： dexmedetomidine 0. 4 μg/kg（ D1 group）,dexmedetomidine 0. 6 μg/kg（ D2 group）,tramadol 1 mg/kg（ T group）,and saline control group（ N group）. These patients received an intravenous injection of dexmedetomidine,tramadol,or saline at the time of surgical suture. The respiratory recovery time,awakening time,extubation time,orientation recovery time,the case of shivering and adverse reactions after surgery were recorded. Results The respiratory recovery time,awakening time,and extubation time in the group D2 were longer than those in the other 3 groups [respiratory recovery time：（ 5. 5 ± 1. 3） min vs.（ 6. 2 ± 1. 2） min vs.（ 5. 1 ±1. 8） min vs.（ 5. 0 ± 0. 9） min,F = 3. 330,P = 0. 024; awakening time：（ 10. 2 ± 1. 3） min vs.（ 11. 5 ± 1. 5） min vs.（ 9. 7 ± 2. 7）min vs.（ 9. 5 ± 1. 8） min,F = 4. 429,P = 0. 006; extubation time：（ 12. 9 ± 1. 5） min vs.（ 14. 2 ± 1. 6） min vs.（ 12. 8 ± 2. 4） min vs.（ 12. 7 ± 1. 9） min,F = 2. 845,P = 0. 043]. Postoperative shivering incidence in the group N was higher than those in the other 3groups（ 3 cases vs. 2 cases vs. 3 cases vs. 9 cases,χ~2= 9. 188,P = 0. 027）. The incidence of nausea and vomiting in the group T was higher than those in the other 3 groups（ 2 cases vs. 1 case vs. 8 cases vs. 4 cases,χ~2= 9. 436,P = 0. 024）. The incidence of tachycardia in the group D2 was higher than those in the other 3 groups（ 3 cases vs. 7 cases vs. 1 case vs. 1 case,χ~2= 9. 412,P =0. 024）. Conclusion Dexmedetomidine 0. 4 μg/kg by intravenous injection can treat postoperative shivering after liposuction effectively and reduce the adverse reactions.
出处
《中国微创外科杂志》
CSCD
北大核心
2017年第10期926-929,共4页
Chinese Journal of Minimally Invasive Surgery
关键词
淋巴水肿
右美托咪定
曲马多
术后寒战
Lymphedema
Dexmedetomidine
Tramadol
Postoperative shivering
