摘要
目的检测碱性成纤维细胞生长因子(basic fibroblast growth factor,b FGF)和成纤维细胞生长因子受体2(basic fibroblast growth factor receptor-2,FGFR-2)在胃癌组织中的表达,并探讨其对淋巴管生成和肿瘤生物学行为的影响。方法采用免疫组化学方法检测59例胃癌及癌旁组织b FGF、FGFR-2及D2-40表达。结果 59例胃癌组织b FGF和FGFR-2表达分别达69.5%(41/59)、64.4%(39/59),明显高于癌旁组织35.6%、33.9%(P<0.05);二者在淋巴结转移组表达高于无转移组,浸润程度越深表达越高。胃癌癌周微淋巴管密度高于正常胃组织(10.89±3.67 vs3.58±0.96),且与淋巴结转移(P<0.05)、b FGF和FGFR-2阳性表达(P<0.05)正相关。结论 b FGF和FGFR-2可能通过促进淋巴管生成参与胃癌浸润转移。
Objective To investigate the expression of basic fibroblast growth factor （bFGF） and basic fibroblast growth factor receptor-2 （FGFR-2） in gastric cancer and their clinicopathological significance. Methods Immunohistochemical technique were used to detect the expressions of bFGF, FGFR-2 and D2- 40 in 59 samples o f gastric cancers and adjacent gastric tissues. Results The expressions of bFGF （ 6 9 . 5 % , 4 1 / 5 9 ） and FGFR-2 （ 6 4 . 4 % , 39/59） in gastric cancers were significantly higher than those in adjacent gastric tissue （P 〈0. 05）. The expressions of bFGF and FGFR- 2 were positively correlated with lymph node metastasis and tumor infiltration depth. The lymphatic microvessel density （LMVD） in gastric cancer was significantly higher than that in normal gastric tissue （ 10. 89 ± 3. 67 3. 58 ± 0.9 6,P 〈 0 .05 ）,which was correlated with lymph nodes metastasis and theexpressions of bFGF and FGFR-2 （P 〈 0. 0 5 ） . Conclusion The expression of bFGF and FGFR-2 is higher in gastric cancer, which might be associated with lymphangiogenesis and contribute to invasion and metastasis in gastric cancer.
出处
《同济大学学报（医学版）》
CAS
2017年第4期17-20,共4页
Journal of Tongji University(Medical Science)
基金
黑龙江省教育厅科学技术研究项目(11541142)
