摘要
目的探讨负荷剂量依折麦布对PCI手术患者血液学指标的影响及对再梗死的预防作用。方法选取2012年10月~2014年10月温州医科大学温州市第三临床学院收治的非ST段抬高性心肌梗死且拟行PCI手术患者240例,进行前瞻性随机分组对照研究。对照组予以常规剂量依哲麦布10 mg/次,qd,研究组予以负荷剂量依折麦布20 mg/次,qd,共服用30 d。用药前、介入后24 h及介入后30 d采血测定炎症因子、心肌损伤及血管内皮功能,同时对比心肌微循环灌注状况,并进行2年随访,记录不良反应情况。结果与治疗前比较,2组用药不同时间点血清炎症因子、心肌损伤及血管内皮功能指标存在差异（P〈0.05）;与对照组比较,研究组介入后24 h、30 d血清hs-CRP、TNF-α、IFN-γ及IL-6含量较低,血清CK-MB、c Tn I、BNP含量较低,血清ET含量较低,NO含量较高（P〈0.05）,研究组用药后心肌微循环灌注改善程度较高（P〈0.05）。随访2年期间无病例脱落现象,2组心血管事件发生率比较差异无统计学意义。结论负荷剂量依折麦布对PCI术后心肌保护作用较强,抑制手术导致的炎症反应及血管内皮损伤,改善心肌微循环灌注。
Objective To investigate the prevention effect of Ezetimibe with loaded dose on hematologic parameters and re-infarction in patients undergoing PCI. Methods 240 cases of patients with non ST segment elevation myocardial infarction performed PCI from October 2012 to October 2014 were selected and randomly divided into two groups,the control group received conventional dose Ezetimibe 10 mg every time,qd,the study group received loading dose ezetimibe 20 mg every time,qd,both two groups treatment 30 days. The inflammatory factors,myocardial injury and vascular endothelial function were compared before,24 h and 30 d after the operation,and patients were followed up for two years,record adverse reactions.Results Compared with before treatment,levels of serum inflammatory factor,myocardial injury and vascular endothelial function index in different time points had differences by single factor analysis of variance（ P〈0. 05）,and compared with the control group,levels of serum hs-CRP,TNF-α,IFN-γ and IL-6 in the study group were lower,levels of serum CK-MB,c Tn I and BNP were lower,the contents of ET in serum were lower,and the contents of NO were higher（ P〈0. 05）. The improvement degree in the study group of myocardial microcirculation perfusion after treatment was higher（ P〈0. 05）. No case shedding phenomenon occurred during the two year follow-up,and there was no statistical significance in the incidence of cardiovascular events between two groups. Conclusion Loading dose of ezetimibe can protect myocardium,and it can inhibit the inflammatory reaction and vascular endothelial injury caused by operation,it also can improve myocardial microcirculation.
作者
林建锋
林伟
林加锋
LIN Jian-feng LIN Wei LIN Jia-feng(Department of Cardiovascular Medicine,Wenzhou Medical University,Wenzhou City the Third Clinical College,Wenzhou 325000,China Department of Cardiovascular Medicine,the Second Affiliated Hospital of Wenzhou Medical University,Wenzhou 325000,China)
出处
《中国生化药物杂志》
CAS
2016年第12期84-86,90,共4页
Chinese Journal of Biochemical Pharmaceutics
关键词
负荷剂量
依折麦布
PCI手术
心肌酶
再梗死
loading dose
ezetimibe
PCI surgery
myocardial enzymes
re-infarction
