摘要
结核病是严重危害人类健康的一类重大传染性疾病,热休克蛋白是在真核和原核细胞中一组结构上非常保守的蛋白质,可作为抗原物质启动固有和适应性免疫应答。已有大量研究表明,一方面Mtb Hsp16.3在结核感染过程中可帮助Mtb逃避巨噬细胞的吞噬杀伤,另一方面其作为疫苗成分又可诱导在抗结核感染中起保护作用的Th1型免疫应答,表明Mtb Hsp16.3在结核感染不同阶段发挥着不同的作用。因此,本文就Mtb Hsp16.3在结核病中作用的研究进展作一综述。
Tuberculosis is a serious infectious disease that seriously endangers human health.Heat shock protein is a highly conserved protein in eukaryotic and prokaryotic cells,and it induces an innate and adaptive immune response as an antigen.Numerous studies have indicated that heat shock protein 16.3(Hsp16.3)can help Mycobacterium tuberculosis to avoid phagocytosis and death by macrophages in the course of tuberculosis infection.As an antigen,Mtb Hsp16.3induces a Th1-type immune response to protect the body from a tuberculosis infection.These facts indicate that Hsp16.3Mtb plays different roles in different stages of tuberculosis infection.Therefore,this article reviews advances in the study of the role of Mtb Hsp16.3in tuberculosis.
作者
秦欢
罗军敏
李姗姗
QIN Huan;LUO Jun-min;LI Shan-shan(Department of Immunology,Zunyi Medical College,Guizhou Province Center for Applied Research and Engineering of Immune-related Molecules,Guizhou,563000,China)
出处
《中国病原生物学杂志》
CSCD
北大核心
2016年第10期955-957,共3页
Journal of Pathogen Biology
基金
国家自然科学基金项目(No.81460249)
贵州省科学技术基金项目(黔科合LH字[2015]7558号)
