摘要
目的分析结缔组织病相关间质性肺病(Connective tissue disease associated interstitial lung disease,CTD-ILD)临床特征。方法回顾性分析305例西京医院临床免疫科CTD-ILD的临床特征及类风湿关节炎间质性肺病(Rheumatoid arthritis associated interstitial lung disease,RA-ILD)和干燥综合征间质性肺病(Sjogren's syndrome associated interstitial lung disease,p SS-ILD)患者胸部高分辨CT特点。结果CTD患者ILD的发病率为11.78%,其中多发性肌炎相关ILD的发病率最高(53.13%),其次为抗中性粒细胞胞浆抗体相关性血管炎(40.74%)、混合结缔组织病(35.14%)和硬皮病(29.73%)。p SS-ILD和RA-ILD在CTD-ILD中所占比例最大,分别为24.92%和23.61%,两者约占所有CTD-ILD的一半。结论CTD患者ILD的发病率高,RA-ILD和p SS-ILD是CTD-ILD的主要疾病,加强对CTD-ILD的早期筛查和早期治疗非常重要。
Objective To analyze the clinical features of connective tissue disease associated interstitial lung disease(CTD-ILD).Methods The clinical manifestation of 305 patients diagnosed CTD-ILD and chest high resolu-tion computed tomography features of rheumatoid arthritis associated interstitial lung disease(RA-ILD)and Sjogren's syndrome associated interstitial lung disease(pSS-ILD)were retrospectively analyzed.Results The total incidence of ILD in CTD was 11.78%.The highest incidence of ILD was polymyositis(53.13%),then was anti-neutrophil cytoplasmic antibody associated vaseulitis(40.74%),mixed connective tissue disease(35.14%)and scleroderma(29.73%).pSS-ILD and RA-ILD were the major part of the total CTD-ILD with the proportion of 24.92%and 23.61%respectively and almost occupied the half of all CTD-ILD patients.Conclusion The incidence of CTD-ILDis very high.pSS-ILD and RA-ILD are the main diseases of CTD-ILD,and the early screening and treatment is very important.
作者
谢荣华
吴振彪
贾俊峰
韩青
朱平
XIE Rong-hua;WU Zhen-biao;JIA Jun-feng;HAN Qing;ZHU Ping(Department of Clinical Immune,Xijing Hospital of the Fourth Military Medical University,Xi'an,Shanxi710032,China)
出处
《临床肺科杂志》
2016年第12期2135-2138,共4页
Journal of Clinical Pulmonary Medicine
基金
国家科技重大专项(No 2014ZX09508002-002)
关键词
结缔组织病
间质性肺病
类风湿关节炎
干燥综合征
connective tissue disease
interstitial lung disease
rheumatoid arthritis
Sjogren's syndrome
