摘要
目的考察炎琥宁和羟丙基倍他环糊精不同摩尔比例制成的溶液和冻干制剂的稳定性,为注射用炎琥宁处方筛选提供依据。方法采用高效液相色谱法对样品进行有关物质检查和稳定性分析评价。结果当炎琥宁和羟丙基倍他环糊精摩尔比例为1∶1以上时,溶液和制剂最为稳定。结论羟丙基倍他环糊精可作为注射用炎琥宁的稳定剂使用。
OBJECTIVE Investigating of the stability of solution and freeze-dried preparation of differentmolar ratio of Potassium Sodium Dehydroandrographolide Succinate and Hydroxypropylbetadex in order to provide the basis for prescription screening of Potassium Sodium Dehydroandrographolide Succinate for Injection. METHODS Using high performance liquid chromatography（ HPLC） method for the examination of related substances of the sample and the stability evaluation. RESULTS When themolar ratio of Potassium Sodium Dehydroandrographolide Succinate and Hydroxypropylbetadex is higher than 1 ∶ 1,the stability of solution and freeze-dried preparation is best. CONCLUTION Hydroxypropylbetadex can be used as a stabilizer for Potassium Sodium Dehydroandrographolide Succinate for Injection.
出处
《海峡药学》
2016年第6期12-14,共3页
Strait Pharmaceutical Journal
关键词
注射用炎琥宁
羟丙基倍他环糊精
稳定性
Potassium Sodium Dehydroandrographolide Succinate for Injection
Hydroxypropylbetadex
Stability
