摘要
以乙二醇二缩水甘油醚为偶联剂,将胍盐低聚物(PHMG)接枝到聚乙烯醇(PVA)上,合成了PVA接枝物(PVA-g-PHMG)。然后,将一定比例的PVA-g-PHMG与明胶共混,制备了抗菌水凝胶敷料(AHD)。通过红外光谱(FTIR)、元素分析证实了PHMG对PVA的接枝反应;通过吸液测试、抗菌测试表征了AHD的理化性能。结果表明:在反应温度℃,wNaOH=0.6%(wt,质量分数,下同),wGDE=8%,反应时间3h时,PVA-g-PHMG中PHMG的接枝效率最高,可达35.5%;当wPHMG>0.94%时,AHD对金黄色葡萄球菌与大肠杆菌的抑菌率可以达到99%以上。
Polyvinyl alcohol grafted oligoguanidine(PVA-g-PHMG)was synthesized using glycol diglycidyl ether as the coupling agent.Antimicrobial hydrogel dressing(AHD)was further prepared by blending PVA-g-PHMG with gelatin.The molecular structures,physical and chemical properties of the prepared AHD were characterized via infrared spectroscopy(FT-IR),element analysis,fluid absorbency test and antimicrobial tests.Results showed that the maximum grafting efficiency(35.5%)could be achieved at the optimal reaction conditions as following:3hof reaction time at 70℃and wNaOH=0.6wt%,wGDE=8wt%.The water vapor transmission of AHD decreased with the increasing of gelatine content.The growth inhibition against E.coli and S.aureus reached over 99%when wPHMG〉0.94wt%.
作者
周雯婷
郭吟竹
李兴茂
管涌
郑安呐
Zhou Wenting;Guo Yinzhu;Li Xingmao;Guan Yong;Zheng Anna(Shanghai Key Laboratory of Advanced Polymeric Materials,Key Laboratory for Ultrafine Materials of Ministry of Education,School of Materials Science and Engineering,East China University of Science and Technology,Shanghai 200237)
出处
《化工新型材料》
CAS
CSCD
北大核心
2016年第6期226-229,共4页
New Chemical Materials
基金
上海市自然科学基金项目(12ZR1407800)
关键词
医用敷料
水凝胶
抗菌
键合
wound dressing
hydrogel
antimicrobial
bonding
