摘要
目的:分析IgG4相关唾液腺炎和有"唾液腺肿大"类似表现的常见唾液腺非肿瘤疾病的特点,明确其临床鉴别诊断要点。方法:回顾分析诊断为IgG4相关唾液腺炎患者的临床资料,与有腺体肿大类似表现的唾液腺非肿瘤疾病进行比较,重点从病史及临床表现、血液免疫学和组织病理学方面比较IgG4相关唾液腺炎与舍格伦综合征(Sjogren’ssyndrome,SS)的差异,应用SAS8.0软件包对数据进行非参数统计。结果:335例唾液腺非肿瘤疾病患者纳入本研究,包括IgG4相关唾液腺炎25例、阻塞性唾液腺炎279例和SS31例。比较IgG4相关唾液腺炎与阻塞性唾液腺炎和SS的疾病特点可见,其在病史及临床检查、血液免疫学和组织病理学等方面均有各自特点,差异显著。结论:IgG4相关唾液腺炎是一类以唾液腺肿大为典型表现的唾液腺慢性炎症,临床上应综合多方面考虑,与其他可能引起唾液腺肿大症状的疾病明确鉴别,准确诊断,为进一步制订合理的治疗方案提供依据。
PURPOSE:To discuss the clinical features of Ig G4-related sclerosing sialadenitis and salivary glands nonneoplastic diseases presenting gland swelling,to make clear the key points of clinical differential diagnosis.METHODS:We retrospectively analyzed and compared the clinical data of Ig G4-related sclerosing sialadenitis with those of salivary glands non-neoplastic diseases especially Sjogren's syndrome(SS)in medical history,clinical examination,serology and pathology.The statistical analysis was performed using SAS 8.0 software package.RESULTS:Three hundred and thirtyfive patients with salivary glands non-neoplastic diseases were included in the study,including 25 Ig G4-related sclerosing sialadenitis,279 obstructive sialadenitis and 31 SS.We compared Ig G4-related sclerosing sialadenitis with the others and found out significant differences in each aspects.CONCLUSIONS:Ig G4-related sclerosing sialadenitis is a kind of chronic salivary gland inflammation with glands swelling.In order to make a definite diagnosis with other salivary glands non-neoplastic diseases,a comprehensive analysis is needed.
作者
王知俊
郑凌艳
浦益萍
谢李松
石欢
俞创奇
WANG Zhi-jun;ZHENG Ling-yan;PU Yi-ping;XIE Li-song;SHI Huan;YU Chuang-qi(Department of Oral Surgery,Shanghai Ninth People's Hospital,College of Stomatology,Shanghai Jiao Tong University School of Medicine,Shanghai Key Laboratory of Stomatology.Shanghai 200011,China)
出处
《中国口腔颌面外科杂志》
CAS
2016年第2期128-133,共6页
China Journal of Oral and Maxillofacial Surgery
基金
国家自然科学基金(81100766)
