摘要
目的:探讨胆汁中肿瘤标志物糖链抗原19-9(carbohydrate antigen 19-9,CA19-9)、癌抗原125(cancer antigen 125,CA125)对胆系恶性肿瘤的临床诊断价值.方法:选取胆系疾病患者共95例,根据病理结果分为恶性肿瘤、良性病变两组,术前抽取血清样本,术中抽取胆汁样本,分别测定血清及胆汁中CA19-9、CA125的水平,进行统计学分析并得出对临床诊断意义.结果:胆系恶性肿瘤组血清及胆汁中CA19-9及CA125水平均显著高于胆系良性疾病组,差异有统计学意义(均P<0.05).胆系良、恶性疾病组胆汁中CA19-9及CA125水平均显著高于血清水平,且差异有统计学意义(均P<0.05).胆汁CA19-9、CA125及双项联合测定的灵敏性为90.48%、83.33%和92.86%,特异性为43.40%、64.15%和72.63%,均优于血清指标(均P<0.05).结论:胆汁中CA19-9及CA125对于胆系恶性肿瘤的诊断价值高于血清指标,且二者联合测定有助于提高胆系恶性肿瘤的临床诊断.
AIM： To evaluate the diagnostic value of bile levels of carbohydrate antigen 19-9（CA19-9） and cancer antigen 125（CA125） in biliary tract carcinoma. METHODS： Ninety-five patients pathologically diagnosed with either biliary tract carcinoma or benign biliary disease were included. Serum and bile samples were taken before and during operation. The levels of CAl9-9 and CA125 in serum and bile were detected, and their diagnostic value was evaluated. RESULTS： The levels of CA19-9 and CA125 in serum and bile were significantly higher in patients with biliary tract carcinoma than in those with benign biliary disease（P 0.05 for all）. The levels of CA19-9 and CA125 in bile were significantly higher than those in serum in both groups of patients（P 0.05 for all）. The sensitivities of CA19-9, CA125 in bile alone and their combination were 90.48%, 83.33% and 92.86%, and the specif icities were 43.40%, 64.15% and 72.63%, respectively. C O N C L U S I O N ： The diagnostic value of CA19-9 and CA125 in bile is higher than that of serum CA19-9 and CA125 in biliary tract carcinoma. Combined detection of tumor makers in bile can improve the diagnosis of biliary tract carcinoma.
出处
《世界华人消化杂志》
CAS
2016年第1期131-135,共5页
World Chinese Journal of Digestology
