摘要
背景:由于3D打印技术具有高度的仿生性和复制精微复杂结构的优势,被广泛应用于骨科、整形美容、医学修复与心血管疾病的诊疗中。目的:综述3D打印技术在构建心脏瓣膜、再生血管、工程心肌组织和心血管疾病模型等方面的研究进展、优势及存在的问题,并展望其临床运用前景。方法:由第一作者检索Pub Med数据库、CNKI数据库2013年4月至2015年4月的相关文献,检索关键词为"3D printing,cardiovascular system,rapid prototyping;3D打印,心血管,快速成型技术"。结果与结论:目前,3D打印技术涉及了心血管研究和应用的各个方面,在组织工程心肌、组织工程心脏瓣膜、组织工程大血管及血管网的构建上已有突破性进展,3D打印方案逐渐完善,其应用已从实验室研究走向临床应用。但在更广泛的运用前还有很多亟待攻克的难题,最为突出的问题之一是如何保证打印器官或组织的血供问题,尽管目前3D打印的管状结构已基本保证了组织器官的血供需求,但毛细血管的超微结构难以通过图像重建模仿,在构建局部微循环方面还有待进一步突破。
BACKGROUND： The 3D printing that has high-level bionic ability and reproduces subtle and complex structure has been widely used in orthopedics,plastic surgery,medical repair and diagnosis and treatment of cardiovascular diseases. OBJECTIVE： To review the research about development,advantages and existing problems of the 3D printing technology in building heart valves,blood vessels,tissue-egnieered myocardial tissue and cardiovascular disease models in recent years and to prospect its clinical applications. METHODS： The Pub Med and CNKI databases were searched by the first author for related papers about 3D printing and cardiovascular system published from April 2013 to April 2015. The key words were ＂3D printing,cardiovascular system,rapid prototyping＂ in English and Chinese,respectively. RESULTS AND CONCLUSION： Currently,the 3D printing technology has be applied widely in cardiovascular system research,and achieved a breakthrough in aspects of constructing tissue-engineered myocardium,heartvalve,great vessels and vascular net. The 3D printing can be improved gradually from the laboratory application to the clinical application. However,there are still many important issues to be solved. One of the key issues is how to guarantee the blood supply of the targeted organs or tissue. Currently,the basic blood supply of the printed tissues and organs is achieved by the printing tube structure. However,to build the regional microcirculation should be improved because the image reconstruction technique is not suitable to imitate the ultrastructure of capillary.
出处
《中国组织工程研究》
CAS
北大核心
2015年第43期7029-7034,共6页
Chinese Journal of Tissue Engineering Research
基金
国家自然科学基金(31100828)
华中科技大学自主创新基金(2013TS145)
国家级大学生创新创业训练项目(20150487075
20150487077)~~
