摘要
目的:观察中西医结合治疗肱骨髁上髁间骨折的临床疗效,以及对血清胰岛素样生长因子-Ⅰ(insulin-like growth factors-Ⅰ,IGF-Ⅰ)和骨形态发生蛋白-2(bone morphogenetic protein bone morphogenetic protein-2,BMP-2)水平的影响。方法:选取88例肱骨髁上髁间骨折气滞血瘀证患者,按随机数字表法分为治疗组和对照组,每组各44例;对照组采取尺骨鹰嘴截骨入路术治疗;治疗组在对照组治疗基础上口服身痛逐瘀汤加减治疗,每日1剂,连续治疗4周。比较两组患者中医症状评分和肘关节功能评分;比较治疗后两组患者临床疗效;检测两组患者血清IGF-Ⅰ和BMP-2水平。结果:治疗组治疗后中医临床症状相关指标评分均显著低于对照组(P<0.01);治疗组有效率为97.72%,对照组有效率为81.81%,治疗组显著优于对照组(P<0.05);治疗组肘关节功能优良率为97.73%,对照组肘关节功能优良率为86.36%,治疗组明显高于对照组(χ2=4.162,P<0.05);治疗组治疗后血清IGF-Ⅰ和BMP-2水平均显著高于对照组,差异有统计学意义(P<0.01)。结论:中西医结合治疗肱骨髁上髁间骨折可明显改善患者临床症状和肘关节功能,提高临床疗效,其提高血清IGF-Ⅰ和BMP-2水平可能与上述治疗效果有关。
Objective：To observe the clinical efficacy of the combination of traditional Chinese and western medicine in treating supra-condylar and intercondylar fractures of humerus and its influences of serum levels of insulin like growth factor-Ⅰ（IGF-Ⅰ）and bone-morphogenetic protein-2（BMP-2）. Methods：88 patients of supracondylar and intercondylar fractures of humerus of the syndrome of Qi stagnation and blood stasis were randomly divided into the treatment group and the control group,each of 44 cases. The control group were given olecranon osteotomy surgery. The treatment group received Shentong Zhuyu Tang（1 dose a day and bid）. Courses of treat-ment for both groups was 4 weeks. TCM symptom scores and elbow function scores in two groups were compared. The clinical efficacy was analyzed between two groups. The serum levels of IGF-Ⅰ and BMP-2 were detected in two groups. Results：The TCM symptom scores were evidently lower in treatment group than control one after treatment（P ﹤ 0. 01）. The total effective rate for treatment group was 97. 72% ,better than control group with 81. 81%（P ﹤ 0. 05）. The fineness rate of elbow function scores in treatment group was 97. 73% ,better than control group with 86. 36%（χ2 = 4. 162,P ﹤ 0. 05）. The serum levels of IGF-Ⅰ and BMP-2 in treatment group were obviously higher than control one with statistical significances after treatment group（P ﹤ 0. 01）. Conclusion：Combination of tradi-tional Chinese and western medicine for the treatment of supracondylar and intercondylar fractures of humerus can evidently improve symptoms,elbow function and clinic effect. The increasing serum levels of IGF-Ⅰ and BMP-2 could be related to the effect above.
出处
《中医学报》
CAS
2015年第9期1282-1284,共3页
Acta Chinese Medicine
关键词
肱骨髁上髁间骨折
身痛逐瘀汤
气滞血瘀证
尺骨鹰嘴截骨入路术
IGF-Ⅰ
BMP-2
supracondylar and intercondylar fractures of humerus
shentong zhuyu tang
syndrome of Qi stagnation and blood stasis
o-lecranon osteotomy surgery
IGF-Ⅰ
BMP-2
